(3-methoxy-5-oxo-4-phenyl-5H-furan-2-ylidene)-(2-methoxy-phenyl)-acetic acid methyl ester

Base Information

Chemical Name:(3-methoxy-5-oxo-4-phenyl-5H-furan-2-ylidene)-(2-methoxy-phenyl)-acetic acid methyl ester
CAS No.:6200-02-8
Molecular Formula:C₂₁H₁₈O₆
Molecular Weight:366.37
Hs Code.:

(3-methoxy-5-oxo-4-phenyl-5<i>H</i>-furan-2-ylidene)-(2-methoxy-phenyl)-acetic acid methyl ester

Synonyms:(3-methoxy-5-oxo-4-phenyl-5H-furan-2-ylidene)-(2-methoxy-phenyl)-acetic acid methyl ester

Suppliers and Price of (3-methoxy-5-oxo-4-phenyl-5H-furan-2-ylidene)-(2-methoxy-phenyl)-acetic acid methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (3-methoxy-5-oxo-4-phenyl-5H-furan-2-ylidene)-(2-methoxy-phenyl)-acetic acid methyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

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Technology Process of (3-methoxy-5-oxo-4-phenyl-5H-furan-2-ylidene)-(2-methoxy-phenyl)-acetic acid methyl ester

There total 6 articles about (3-methoxy-5-oxo-4-phenyl-5H-furan-2-ylidene)-(2-methoxy-phenyl)-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: (3-methoxy-5-oxo-4-trifluoromethanesulfonyloxy-5H-furan-2-ylidene)-(2-methoxy-phenyl)-acetic acid methyl ester

: 98-80-6
phenylboronic acid

: 6200-02-8
(3-methoxy-5-oxo-4-phenyl-5H-furan-2-ylidene)-(2-methoxy-phenyl)-acetic acid methyl ester

Guidance literature:: With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; for 4h; Heating;
DOI:10.1002/ejoc.200500142

Reference yield:

: 866556-32-3
4-methoxy-2-(2-methoxy-phenyl)-3-oxo-butyric acid methyl ester

: 6200-02-8
(3-methoxy-5-oxo-4-phenyl-5H-furan-2-ylidene)-(2-methoxy-phenyl)-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 95 percent / triethylamine / benzene / 72 h

2.1: LDA / tetrahydrofuran / 1 h / -78 °C

2.2: 97 percent / tetrahydrofuran / 12 h / 20 °C

3.1: 63 percent / Me₃SiOTf / CH₂Cl₂ / 14 h / -78 - 20 °C

4.1: 53 percent / pyridine / CH₂Cl₂ / 4 h / -78 - -10 °C

5.1: 92 percent / K₃PO₄; [Pd(PPh₃)4] / dioxane / 4 h / Heating

With pyridine; potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; trimethylsilyl trifluoromethanesulfonate; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; benzene; 5.1: Suzuki reaction;
DOI:10.1002/ejoc.200500142

Reference yield:

: 866556-33-4
(Z)-4-Methoxy-2-(2-methoxy-phenyl)-3-trimethylsilanyloxy-but-2-enoic acid methyl ester

: 6200-02-8
(3-methoxy-5-oxo-4-phenyl-5H-furan-2-ylidene)-(2-methoxy-phenyl)-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: LDA / tetrahydrofuran / 1 h / -78 °C

1.2: 97 percent / tetrahydrofuran / 12 h / 20 °C

2.1: 63 percent / Me₃SiOTf / CH₂Cl₂ / 14 h / -78 - 20 °C

3.1: 53 percent / pyridine / CH₂Cl₂ / 4 h / -78 - -10 °C

4.1: 92 percent / K₃PO₄; [Pd(PPh₃)4] / dioxane / 4 h / Heating

With pyridine; potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; trimethylsilyl trifluoromethanesulfonate; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; 4.1: Suzuki reaction;
DOI:10.1002/ejoc.200500142