methyl 2-ethyl-2-[[4-[5-[4-(trifluoro-methyl)-1-(2-trimethylsilylethoxymethyl)imidazol-2-yl]-2-pyridyl]phenoxy]methyl]-butanoate

Base Information

Chemical Name:methyl 2-ethyl-2-[[4-[5-[4-(trifluoro-methyl)-1-(2-trimethylsilylethoxymethyl)imidazol-2-yl]-2-pyridyl]phenoxy]methyl]-butanoate
CAS No.:1382999-42-9
Molecular Formula:C₂₉H₃₈F₃N₃O₄Si
Molecular Weight:577.719
Hs Code.:

Synonyms:methyl 2-ethyl-2-[[4-[5-[4-(trifluoro-methyl)-1-(2-trimethylsilylethoxymethyl)imidazol-2-yl]-2-pyridyl]phenoxy]methyl]-butanoate

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Chemical Property of methyl 2-ethyl-2-[[4-[5-[4-(trifluoro-methyl)-1-(2-trimethylsilylethoxymethyl)imidazol-2-yl]-2-pyridyl]phenoxy]methyl]-butanoate

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Technology Process of methyl 2-ethyl-2-[[4-[5-[4-(trifluoro-methyl)-1-(2-trimethylsilylethoxymethyl)imidazol-2-yl]-2-pyridyl]phenoxy]methyl]-butanoate

There total 6 articles about methyl 2-ethyl-2-[[4-[5-[4-(trifluoro-methyl)-1-(2-trimethylsilylethoxymethyl)imidazol-2-yl]-2-pyridyl]phenoxy]methyl]-butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1382999-40-7
methyl 2-ethyl-2-(p-tolylsulfonyloxymethyl)-butanoate

: 1382998-73-3
4-{5-[4-(trifluoromethyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl]pyridin-2-yl}phenol

: 1382999-42-9
methyl 2-ethyl-2-[[4-[5-[4-(trifluoro-methyl)-1-(2-trimethylsilylethoxymethyl)imidazol-2-yl]-2-pyridyl]phenoxy]methyl]-butanoate

Guidance literature:: 4-{5-[4-(trifluoromethyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl]pyridin-2-yl}phenol; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

methyl 2-ethyl-2-(p-tolylsulfonyloxymethyl)-butanoate; In N,N-dimethyl-formamide; at 100 ℃; Cooling with ice;

Reference yield:

: 149806-06-4
6-bromonicotinaldehyde

: 1382999-42-9
methyl 2-ethyl-2-[[4-[5-[4-(trifluoro-methyl)-1-(2-trimethylsilylethoxymethyl)imidazol-2-yl]-2-pyridyl]phenoxy]methyl]-butanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium acetate / water / 0.5 h / 95 °C

1.2: 20 °C / Cooling with ice

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / Inert atmosphere; Cooling with ice

2.2: 20 °C / Cooling with ice

3.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; N,N-dimethyl-formamide / 65 °C / Inert atmosphere

4.1: hydrogen / palladium on activated charcoal / tetrahydrofuran; methanol / 5 h / 20 °C / Inert atmosphere

5.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C

5.2: 100 °C / Cooling with ice

With hydrogen; sodium acetate; sodium hydride; sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium on activated charcoal; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;

Reference yield:

: 1382998-88-0
2-bromo-5-[4-(trifluoromethyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazole-2-yl]pyridine

: 1382999-42-9
methyl 2-ethyl-2-[[4-[5-[4-(trifluoro-methyl)-1-(2-trimethylsilylethoxymethyl)imidazol-2-yl]-2-pyridyl]phenoxy]methyl]-butanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; N,N-dimethyl-formamide / 65 °C / Inert atmosphere

2.1: hydrogen / palladium on activated charcoal / tetrahydrofuran; methanol / 5 h / 20 °C / Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C

3.2: 100 °C / Cooling with ice

With hydrogen; sodium hydride; sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium on activated charcoal; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;