2-[4-(benzyloxy)phenyl]-5-[4-(trifluoro-methyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl]pyridine

Base Information

Chemical Name:2-[4-(benzyloxy)phenyl]-5-[4-(trifluoro-methyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl]pyridine
CAS No.:1383001-88-4
Molecular Formula:C₂₈H₃₀F₃N₃O₂Si
Molecular Weight:525.646
Hs Code.:

Synonyms:2-[4-(benzyloxy)phenyl]-5-[4-(trifluoro-methyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl]pyridine

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Chemical Property of 2-[4-(benzyloxy)phenyl]-5-[4-(trifluoro-methyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl]pyridine

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Technology Process of 2-[4-(benzyloxy)phenyl]-5-[4-(trifluoro-methyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl]pyridine

There total 4 articles about 2-[4-(benzyloxy)phenyl]-5-[4-(trifluoro-methyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1382998-88-0
2-bromo-5-[4-(trifluoromethyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazole-2-yl]pyridine

: 146631-00-7
[4-(benzyloxy)phenyl]boronic acid

: 1383001-88-4
2-[4-(benzyloxy)phenyl]-5-[4-(trifluoro-methyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl]pyridine

Guidance literature:: With sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In water; N,N-dimethyl-formamide; at 65 ℃; Inert atmosphere;

Reference yield:

: 149806-06-4
6-bromonicotinaldehyde

: 1383001-88-4
2-[4-(benzyloxy)phenyl]-5-[4-(trifluoro-methyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium acetate / water / 0.5 h / 95 °C

1.2: 20 °C / Cooling with ice

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / Inert atmosphere; Cooling with ice

2.2: 20 °C / Cooling with ice; Inert atmosphere

3.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / water; N,N-dimethyl-formamide / 6 h / 65 °C / Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium acetate; sodium hydride; sodium carbonate; In water; N,N-dimethyl-formamide; 3.1: |Suzuki Coupling;

Reference yield:

: 1383001-87-3
2-bromo-5-[5-(trifluoromethyl)-1H-imidazole-2-yl]pyridine

: 1383001-88-4
2-[4-(benzyloxy)phenyl]-5-[4-(trifluoro-methyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl]pyridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / Inert atmosphere; Cooling with ice

1.2: 20 °C / Cooling with ice; Inert atmosphere

2.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / water; N,N-dimethyl-formamide / 6 h / 65 °C / Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium hydride; sodium carbonate; In water; N,N-dimethyl-formamide; 2.1: |Suzuki Coupling;