N-[(2-hydroxyphenyl)methyl]-N-(4-phenoxy-3-pyridinyl)acetamide

Base Information

• Chemical Name: N-[(2-hydroxyphenyl)methyl]-N-(4-phenoxy-3-pyridinyl)acetamide
• CAS No.: 1005325-42-7
• Molecular Formula: C₂₀H₁₈N₂O₃
• Molecular Weight: 334.375
• Mol file: 1005325-42-7.mol

Synonyms:N-[(2-hydroxyphenyl)methyl]-N-(4-phenoxy-3-pyridinyl)acetamide

Chemical Property of N-[(2-hydroxyphenyl)methyl]-N-(4-phenoxy-3-pyridinyl)acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of N-[(2-hydroxyphenyl)methyl]-N-(4-phenoxy-3-pyridinyl)acetamide

There total 2 articles about N-[(2-hydroxyphenyl)methyl]-N-(4-phenoxy-3-pyridinyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

2-((4-phenoxypyridin-3-ylamino)methyl)phenol (1005325-41-6) + acetic anhydride (108-24-7) → N-[(2-hydroxyphenyl)methyl]-N-(4-phenoxy-3-pyridinyl)acetamide (1005325-42-7)

Guidance literature:

2-((4-phenoxypyridin-3-ylamino)methyl)phenol; acetic anhydride; In acetic acid; for 3h; Heating;

With potassium hydroxide; In methanol; at 20 ℃; for 3h; Further stages.;

DOI:10.1021/jm0707370

Reference yield:

C22H20N2O4 → N-[(2-hydroxyphenyl)methyl]-N-(4-phenoxy-3-pyridinyl)acetamide (1005325-42-7)

Guidance literature:

With lithium hydroxide; In methanol; at 20 ℃;

DOI:10.1016/j.bmcl.2009.08.051

Reference yield: 56.2%

N-[(2-hydroxyphenyl)methyl]-N-(4-phenoxy-3-pyridinyl)acetamide (1005325-42-7) + [18F]fluoromethylene toluene-4-sulfonate (113426-16-7) → N-acetyl-N-(2-[18F]fluoromethoxybenzyl)-2-phenoxy5-pyridinamine

Guidance literature:

N-[(2-hydroxyphenyl)methyl]-N-(4-phenoxy-3-pyridinyl)acetamide; [18F]fluoromethylene toluene-4-sulfonate; With 18-crown-6 ether; caesium carbonate; In acetonitrile; at 120 ℃; for 0.166667h;

With 1-methyl-2,3,4,6,7,8-hexahydro-1H-pyrimido[1,2-a]pyrimidine; In acetonitrile; at 20 ℃; for 0.0833333h;

DOI:10.1039/c9cc04901k

upstream raw materials:

2-((4-phenoxypyridin-3-ylamino)methyl)phenol

acetic anhydride

Downstream raw materials:

N-(2-[⁽¹¹⁾C]methoxybenzyl)-N-(4-phenoxy-3-pyridinyl)acetamide

PBR₂₈