2-N-(N,N-dimethylaminomethylidenyl)-N₁-benzoyl-7-deaza-7-iodo-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-2'-deoxyguanosine

Base Information

• Chemical Name: 2-N-(N,N-dimethylaminomethylidenyl)-N₁-benzoyl-7-deaza-7-iodo-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-2'-deoxyguanosine
• CAS No.: 1288999-14-3
• Molecular Formula: C₃₃H₄₈IN₅O₆Si₂
• Molecular Weight: 793.85

Synonyms:2-N-(N,N-dimethylaminomethylidenyl)-N₁-benzoyl-7-deaza-7-iodo-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-2'-deoxyguanosine

Chemical Property of 2-N-(N,N-dimethylaminomethylidenyl)-N₁-benzoyl-7-deaza-7-iodo-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-2'-deoxyguanosine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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Useful:

Technology Process of 2-N-(N,N-dimethylaminomethylidenyl)-N₁-benzoyl-7-deaza-7-iodo-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-2'-deoxyguanosine

There total 4 articles about 2-N-(N,N-dimethylaminomethylidenyl)-N₁-benzoyl-7-deaza-7-iodo-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-2'-deoxyguanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

2-N-(N,N-dimethylaminomethylidenyl)-7-deaza-7-iodo-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-2'-deoxyguanosine (1288998-90-2) + benzoyl chloride (98-88-4) → 2-N-(N,N-dimethylaminomethylidenyl)-N1-benzoyl-7-deaza-7-iodo-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-2'-deoxyguanosine (1288999-14-3)

Guidance literature:

In pyridine; dichloromethane; at 0 - 20 ℃;

DOI:10.1002/chem.201001952

Reference yield:

C23H39IN4O5Si2 (213623-67-7) → 2-N-(N,N-dimethylaminomethylidenyl)-N1-benzoyl-7-deaza-7-iodo-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-2'-deoxyguanosine (1288999-14-3)

Guidance literature:

Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere

2: pyridine; dichloromethane / 0 - 20 °C

In pyridine; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/chem.201001952

Reference yield:

1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane (69304-37-6) → 2-N-(N,N-dimethylaminomethylidenyl)-N1-benzoyl-7-deaza-7-iodo-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-2'-deoxyguanosine (1288999-14-3)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / 20.5 h / 0 - 20 °C / Inert atmosphere

2: N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere

3: pyridine; dichloromethane / 0 - 20 °C

In pyridine; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/chem.201001952

upstream raw materials:

C₂₃H₃₉IN₄O₅Si₂

2-N-(N,N-dimethylaminomethylidenyl)-7-deaza-7-iodo-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-2'-deoxyguanosine

benzoyl chloride

1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane

Downstream raw materials:

2-N-(N,N-dimethylaminomethylidenyl)-N₁-benzoyl-7-deaza-7-iodo-2'-deoxyguanosine

2-N-(N,N-dimethylaminomethylidenyl)-N₁-benzoyl-7-deaza-7-iodo-5'-O-(4-monomethoxytrityl)-2'-deoxyguanosine

2-N-(N,N-dimethylaminomethylidenyl)-N₁-benzoyl-7-deaza-7-iodo-3'-O-(2-cyanoethyl)-5'-O-(4-monomethoxytrityl)-2'-deoxyguanosine

2-N-(N,N-dimethylaminomethylidenyl)-N₃-benzoyl-7-deaza-7-iodo-3'-O-(2-cyanoethyl)-2'-deoxyguanosine

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