(S)-tert-butyl 2-((S)-7-(2-methoxy-2-oxoethoxy)-3-(4-methoxyphenylcarbamoyl)-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)pyrrolidine-1-carboxylate

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Chemical Name:(S)-tert-butyl 2-((S)-7-(2-methoxy-2-oxoethoxy)-3-(4-methoxyphenylcarbamoyl)-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)pyrrolidine-1-carboxylate
CAS No.:1287261-39-5
Molecular Formula:C₃₀H₃₇N₃O₈
Molecular Weight:567.639
Hs Code.:

(S)-tert-butyl 2-((S)-7-(2-methoxy-2-oxoethoxy)-3-(4-methoxyphenylcarbamoyl)-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)pyrrolidine-1-carboxylate

Synonyms:(S)-tert-butyl 2-((S)-7-(2-methoxy-2-oxoethoxy)-3-(4-methoxyphenylcarbamoyl)-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)pyrrolidine-1-carboxylate

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Chemical Property of (S)-tert-butyl 2-((S)-7-(2-methoxy-2-oxoethoxy)-3-(4-methoxyphenylcarbamoyl)-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)pyrrolidine-1-carboxylate

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Technology Process of (S)-tert-butyl 2-((S)-7-(2-methoxy-2-oxoethoxy)-3-(4-methoxyphenylcarbamoyl)-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)pyrrolidine-1-carboxylate

There total 7 articles about (S)-tert-butyl 2-((S)-7-(2-methoxy-2-oxoethoxy)-3-(4-methoxyphenylcarbamoyl)-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 15761-39-4,59433-50-0
1-(tert-butoxycarbonyl)-L-proline

: 1287261-33-9
(S)-methyl 2-((3-((4-methoxyphenyl)carbamoyl)-1,2,3,4-tetrahydroisoquinolin-7-yl)oxy) acetate

: 1287261-39-5
(S)-tert-butyl 2-((S)-7-(2-methoxy-2-oxoethoxy)-3-(4-methoxyphenylcarbamoyl)-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)pyrrolidine-1-carboxylate

Guidance literature:: 1-(tert-butoxycarbonyl)-L-proline; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In tetrahydrofuran; at 20 ℃; for 0.25h;

(S)-methyl 2-((3-((4-methoxyphenyl)carbamoyl)-1,2,3,4-tetrahydroisoquinolin-7-yl)oxy) acetate; In tetrahydrofuran; for 8h;
DOI:10.1021/jm101605z

Reference yield:

: 1223620-63-0
(S)-tert-butyl 7-(2-methoxy-2-oxoethoxy)-3-((4-methoxyphenyl)carbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

: 1287261-39-5
(S)-tert-butyl 2-((S)-7-(2-methoxy-2-oxoethoxy)-3-(4-methoxyphenylcarbamoyl)-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine; trifluoroacetic acid / dichloromethane

2.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / tetrahydrofuran / 0.25 h / 20 °C

2.2: 8 h

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm101605z

Reference yield:

: 1223620-39-0
(S)-tert-butyl 7-hydroxy-3-((4-methoxyphenyl)carbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

: 1287261-39-5
(S)-tert-butyl 2-((S)-7-(2-methoxy-2-oxoethoxy)-3-(4-methoxyphenylcarbamoyl)-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide

2.1: triethylamine; trifluoroacetic acid / dichloromethane

3.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / tetrahydrofuran / 0.25 h / 20 °C

3.2: 8 h

With potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm101605z