(S)-methyl 2-((3-((4-methoxyphenyl)carbamoyl)-1,2,3,4-tetrahydroisoquinolin-7-yl)oxy) acetate

Base Information

Chemical Name:(S)-methyl 2-((3-((4-methoxyphenyl)carbamoyl)-1,2,3,4-tetrahydroisoquinolin-7-yl)oxy) acetate
CAS No.:1287261-33-9
Molecular Formula:C₂₀H₂₂N₂O₅
Molecular Weight:370.405
Hs Code.:

Synonyms:(S)-methyl 2-((3-((4-methoxyphenyl)carbamoyl)-1,2,3,4-tetrahydroisoquinolin-7-yl)oxy) acetate

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Chemical Property of (S)-methyl 2-((3-((4-methoxyphenyl)carbamoyl)-1,2,3,4-tetrahydroisoquinolin-7-yl)oxy) acetate

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Technology Process of (S)-methyl 2-((3-((4-methoxyphenyl)carbamoyl)-1,2,3,4-tetrahydroisoquinolin-7-yl)oxy) acetate

There total 6 articles about (S)-methyl 2-((3-((4-methoxyphenyl)carbamoyl)-1,2,3,4-tetrahydroisoquinolin-7-yl)oxy) acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1223620-63-0
(S)-tert-butyl 7-(2-methoxy-2-oxoethoxy)-3-((4-methoxyphenyl)carbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

: 1287261-33-9
(S)-methyl 2-((3-((4-methoxyphenyl)carbamoyl)-1,2,3,4-tetrahydroisoquinolin-7-yl)oxy) acetate

Guidance literature:: With triethylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/jm101605z

Reference yield:

: 300-39-0
3,5-diiodo-l-tyrosine

: 1287261-33-9
(S)-methyl 2-((3-((4-methoxyphenyl)carbamoyl)-1,2,3,4-tetrahydroisoquinolin-7-yl)oxy) acetate

Guidance literature:: Multi-step reaction with 6 steps

1: hydrogenchloride / 1,2-dimethoxyethane / 18 h / 72 - 75 °C

2: sodium hydroxide / tetrahydrofuran

3: palladium 10% on activated carbon; hydrogen; triethylamine / methanol

4: benzotriazol-1-ol; dicyclohexyl-carbodiimide / tetrahydrofuran

5: potassium carbonate / N,N-dimethyl-formamide

6: triethylamine; trifluoroacetic acid / dichloromethane

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; potassium carbonate; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm101605z

Reference yield:

: 142335-42-0
(3S)-2-(tert-butoxycarbonyl)-7-hydroxy-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid

: 1287261-33-9
(S)-methyl 2-((3-((4-methoxyphenyl)carbamoyl)-1,2,3,4-tetrahydroisoquinolin-7-yl)oxy) acetate

Guidance literature:: Multi-step reaction with 3 steps

1: benzotriazol-1-ol; dicyclohexyl-carbodiimide / tetrahydrofuran

2: potassium carbonate / N,N-dimethyl-formamide

3: triethylamine; trifluoroacetic acid / dichloromethane

With potassium carbonate; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm101605z