2-(1,2-dihydroxyethyl)-4,6-dimethoxy-2-(4-methoxyphenyl)-2,3-dihydrobenzofuran

Base Information

Chemical Name:2-(1,2-dihydroxyethyl)-4,6-dimethoxy-2-(4-methoxyphenyl)-2,3-dihydrobenzofuran
CAS No.:275816-98-3
Molecular Formula:C₁₉H₂₂O₆
Molecular Weight:346.38
Hs Code.:

Synonyms:2-(1,2-dihydroxyethyl)-4,6-dimethoxy-2-(4-methoxyphenyl)-2,3-dihydrobenzofuran

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Chemical Property of 2-(1,2-dihydroxyethyl)-4,6-dimethoxy-2-(4-methoxyphenyl)-2,3-dihydrobenzofuran

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Technology Process of 2-(1,2-dihydroxyethyl)-4,6-dimethoxy-2-(4-methoxyphenyl)-2,3-dihydrobenzofuran

There total 5 articles about 2-(1,2-dihydroxyethyl)-4,6-dimethoxy-2-(4-methoxyphenyl)-2,3-dihydrobenzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 275816-97-2
4,6-dimethoxy-2-(4-methoxyphenyl)-2-vinyl-2,3-dihydrobenzofuran

: 275816-98-3
2-(1,2-dihydroxyethyl)-4,6-dimethoxy-2-(4-methoxyphenyl)-2,3-dihydrobenzofuran

Guidance literature:: With osmium(VIII) oxide; N-methyl-2-indolinone; In tetrahydrofuran; at 20 ℃; for 20h;
DOI:10.3987/com-99-8839

Reference yield:

: 275816-96-1
(2Z)-1-(2,4-dimethoxy-6-hydroxyphenyl)-4-methoxycarbonyloxy-2-(4-methoxyphenyl)-2-butene

: 275816-98-3
2-(1,2-dihydroxyethyl)-4,6-dimethoxy-2-(4-methoxyphenyl)-2,3-dihydrobenzofuran

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / Pd(PPh₃)4 / acetonitrile / 2 h / 20 °C

2: 100 percent / aq. OsO₄; NMO / tetrahydrofuran / 20 h / 20 °C

With osmium(VIII) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; N-methyl-2-indolinone; In tetrahydrofuran; acetonitrile; 1: Cyclization / 2: Oxidation;
DOI:10.3987/com-99-8839

Reference yield:

: (2Z)-4-(6-tert-butyldimethylsilyloxy-2,4-dimethoxyphenyl)-(4-methoxyphenyl)-2-butenal

: 275816-98-3
2-(1,2-dihydroxyethyl)-4,6-dimethoxy-2-(4-methoxyphenyl)-2,3-dihydrobenzofuran

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / DIBALH / CH₂Cl₂; hexane / 0.67 h / -78 °C

2: 100 percent / pyridine / CH₂Cl₂ / 0.5 h / 0 °C

3: 100 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 0.25 h / 0 °C

4: 100 percent / Pd(PPh₃)4 / acetonitrile / 2 h / 20 °C

5: 100 percent / aq. OsO₄; NMO / tetrahydrofuran / 20 h / 20 °C

With pyridine; osmium(VIII) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; N-methyl-2-indolinone; tetrabutyl ammonium fluoride; diisobutylaluminium hydride; In tetrahydrofuran; hexane; dichloromethane; acetonitrile; 1: Reduction / 2: Esterification / 3: desilylation / 4: Cyclization / 5: Oxidation;
DOI:10.3987/com-99-8839