2-[4-(ethylsulfonyl)phenyl]-2-methyl-N-[4-phenyl-5-(phenylcarbonyl)-1,3-thiazol-2-yl]propanamide

Base Information

Chemical Name:2-[4-(ethylsulfonyl)phenyl]-2-methyl-N-[4-phenyl-5-(phenylcarbonyl)-1,3-thiazol-2-yl]propanamide
CAS No.:1363178-84-0
Molecular Formula:C₂₈H₂₆N₂O₄S₂
Molecular Weight:518.657
Hs Code.:

Synonyms:2-[4-(ethylsulfonyl)phenyl]-2-methyl-N-[4-phenyl-5-(phenylcarbonyl)-1,3-thiazol-2-yl]propanamide

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Chemical Property of 2-[4-(ethylsulfonyl)phenyl]-2-methyl-N-[4-phenyl-5-(phenylcarbonyl)-1,3-thiazol-2-yl]propanamide

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Technology Process of 2-[4-(ethylsulfonyl)phenyl]-2-methyl-N-[4-phenyl-5-(phenylcarbonyl)-1,3-thiazol-2-yl]propanamide

There total 8 articles about 2-[4-(ethylsulfonyl)phenyl]-2-methyl-N-[4-phenyl-5-(phenylcarbonyl)-1,3-thiazol-2-yl]propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1363179-12-7
2-(4-(ethylsulfonyl)phenyl)-2-methylpropanoic acid

: 17279-56-0
(2-amino-4-phenyl-1,3-thiazol-5-yl)(phenyl)methanone

: 1363178-84-0
2-[4-(ethylsulfonyl)phenyl]-2-methyl-N-[4-phenyl-5-(phenylcarbonyl)-1,3-thiazol-2-yl]propanamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 72h;

Reference yield:

: ethyl 2-(4-(ethylsulfonyl)phenyl)acetate

: 1363178-84-0
2-[4-(ethylsulfonyl)phenyl]-2-methyl-N-[4-phenyl-5-(phenylcarbonyl)-1,3-thiazol-2-yl]propanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide; water / ethanol / 20 °C

1.2: pH 1

2.1: caesium carbonate / N,N-dimethyl-formamide / 20 °C

2.2: pH 3

3.1: sodium hydroxide; water / ethanol / 3 h / 20 °C

3.2: pH 3

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 72 h / 20 °C

With water; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1197-55-3
4-aminophenylacetic acid

: 1363178-84-0
2-[4-(ethylsulfonyl)phenyl]-2-methyl-N-[4-phenyl-5-(phenylcarbonyl)-1,3-thiazol-2-yl]propanamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: hydrogenchloride; sodium nitrite / water / 0.75 h / 0 °C

1.2: 20 - 45 °C

2.1: potassium hydroxide; water / ethanol / 20 h / Reflux

3.1: potassium carbonate / N,N-dimethyl-formamide / 2.5 h / 20 °C

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C

5.1: sodium hydroxide; water / ethanol / 20 °C

5.2: pH 1

6.1: caesium carbonate / N,N-dimethyl-formamide / 20 °C

6.2: pH 3

7.1: sodium hydroxide; water / ethanol / 3 h / 20 °C

7.2: pH 3

8.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 72 h / 20 °C

With hydrogenchloride; water; potassium carbonate; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-chloro-benzenecarboperoxoic acid; potassium hydroxide; sodium hydroxide; sodium nitrite; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;