5-bromomethyl-1-(2,6-difluoro-benzyl)-3-isobutyl-6-(4-methoxy-phenyl)-1H-thieno[2,3-d]pyrimidine-2,4-dione

Base Information

Chemical Name:5-bromomethyl-1-(2,6-difluoro-benzyl)-3-isobutyl-6-(4-methoxy-phenyl)-1H-thieno[2,3-d]pyrimidine-2,4-dione
CAS No.:181817-79-8
Molecular Formula:C₂₅H₂₃BrF₂N₂O₃S
Molecular Weight:549.436
Hs Code.:

5-bromomethyl-1-(2,6-difluoro-benzyl)-3-isobutyl-6-(4-methoxy-phenyl)-1<i>H</i>-thieno[2,3-<i>d</i>]pyrimidine-2,4-dione

Synonyms:5-bromomethyl-1-(2,6-difluoro-benzyl)-3-isobutyl-6-(4-methoxy-phenyl)-1H-thieno[2,3-d]pyrimidine-2,4-dione

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Chemical Property of 5-bromomethyl-1-(2,6-difluoro-benzyl)-3-isobutyl-6-(4-methoxy-phenyl)-1H-thieno[2,3-d]pyrimidine-2,4-dione

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Technology Process of 5-bromomethyl-1-(2,6-difluoro-benzyl)-3-isobutyl-6-(4-methoxy-phenyl)-1H-thieno[2,3-d]pyrimidine-2,4-dione

There total 5 articles about 5-bromomethyl-1-(2,6-difluoro-benzyl)-3-isobutyl-6-(4-methoxy-phenyl)-1H-thieno[2,3-d]pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 181817-66-3
1-(2,6-difluorobenzyl)-3-isobutyl-6-(4-methoxyphenyl)-5-methylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

: 181817-79-8
5-bromomethyl-1-(2,6-difluoro-benzyl)-3-isobutyl-6-(4-methoxy-phenyl)-1H-thieno[2,3-d]pyrimidine-2,4-dione

Guidance literature:: With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In chlorobenzene; at 90 ℃;
DOI:10.1021/jm020180i

Reference yield:

: 122-84-9
4-methoxybenzyl methyl ketone

: 181817-79-8
5-bromomethyl-1-(2,6-difluoro-benzyl)-3-isobutyl-6-(4-methoxy-phenyl)-1H-thieno[2,3-d]pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 5 steps

1.1: NH₄OAc; AcOH / toluene / 20 h / Heating

1.2: 40 percent / sulfur / ethanol / 2 h / 65 °C

2.1: toluene / 96 h / Heating

3.1: 1.61 g / NaOMe / methanol / 16 h / 20 °C

4.1: 73 percent / KI; K₂CO₃ / dimethylformamide / 20 °C

5.1: NBS; AIBN / chlorobenzene / 90 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); ammonium acetate; sodium methylate; potassium carbonate; acetic acid; potassium iodide; In methanol; N,N-dimethyl-formamide; chlorobenzene; toluene;
DOI:10.1021/jm020180i

Reference yield:

: 181817-46-9
3-isobutyl-6-(4-methoxyphenyl)-5-methylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

: 181817-79-8
5-bromomethyl-1-(2,6-difluoro-benzyl)-3-isobutyl-6-(4-methoxy-phenyl)-1H-thieno[2,3-d]pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 73 percent / KI; K₂CO₃ / dimethylformamide / 20 °C

2: NBS; AIBN / chlorobenzene / 90 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; chlorobenzene;
DOI:10.1021/jm020180i