2-(4-methoxybenzyl)-2H-tetrazole-5-carbonyl chloride

Base Information

• Chemical Name: 2-(4-methoxybenzyl)-2H-tetrazole-5-carbonyl chloride
• CAS No.: 100245-19-0
• Molecular Formula: C₁₀H₉ClN₄O₂
• Molecular Weight: 252.66
• Mol file: 100245-19-0.mol

Synonyms:2-(4-methoxybenzyl)-2H-tetrazole-5-carbonyl chloride

Chemical Property of 2-(4-methoxybenzyl)-2H-tetrazole-5-carbonyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-methoxybenzyl)-2H-tetrazole-5-carbonyl chloride

There total 2 articles about 2-(4-methoxybenzyl)-2H-tetrazole-5-carbonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

potassium 2-(p-methoxybenzyl)tetrazole-5-carboxylate (70978-33-5) → 2-(4-methoxybenzyl)-2H-tetrazole-5-carbonyl chloride (100245-19-0)

Guidance literature:

With pyridine; thionyl chloride; In toluene; at 20 ℃; for 1h;

DOI:10.1021/jm00154a019

Reference yield:

p-methoxybenzyl chloride (824-94-2) → 2-(4-methoxybenzyl)-2H-tetrazole-5-carbonyl chloride (100245-19-0)

Guidance literature:

Multi-step reaction with 2 steps

1: triethanolamine / N,N-dimethyl-formamide; ethanol; water

2: thionyl chloride / toluene

With thionyl chloride; triethanolamine; In ethanol; water; N,N-dimethyl-formamide; toluene;

Reference yield:

(R)-ethyl 3-amino-4-(3'-chlorobiphenyl-4-yl)butanoate hydrochloride (1257443-03-0) + 2-(4-methoxybenzyl)-2H-tetrazole-5-carbonyl chloride (100245-19-0) → C28H28ClN5O4

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 0.0833333h;

upstream raw materials:

potassium 2-(p-methoxybenzyl)tetrazole-5-carboxylate

p-methoxybenzyl chloride

Downstream raw materials:

N-(3-acetyl-5-ethyl-2-hydroxyphenyl)-2-(4-methoxybenzyl)tetrazole-5-carboxamide

Refernces

• 1、 -. "METHOD OF TREATING CONTRAST-INDUCED NEPHROPATHY". . . Retrieved 2012/05/21.