N-(3-acetyl-5-ethyl-2-hydroxyphenyl)-2-(4-methoxybenzyl)tetrazole-5-carboxamide

Base Information

• Chemical Name: N-(3-acetyl-5-ethyl-2-hydroxyphenyl)-2-(4-methoxybenzyl)tetrazole-5-carboxamide
• CAS No.: 70978-04-0
• Molecular Formula: C₂₀H₂₁N₅O₄
• Molecular Weight: 395.418
• Mol file: 70978-04-0.mol

Synonyms:N-(3-acetyl-5-ethyl-2-hydroxyphenyl)-2-(4-methoxybenzyl)tetrazole-5-carboxamide

Chemical Property of N-(3-acetyl-5-ethyl-2-hydroxyphenyl)-2-(4-methoxybenzyl)tetrazole-5-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(3-acetyl-5-ethyl-2-hydroxyphenyl)-2-(4-methoxybenzyl)tetrazole-5-carboxamide

There total 5 articles about N-(3-acetyl-5-ethyl-2-hydroxyphenyl)-2-(4-methoxybenzyl)tetrazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-ethyl-6-hydroxyacetophenone (24539-92-2) → N-(3-acetyl-5-ethyl-2-hydroxyphenyl)-2-(4-methoxybenzyl)tetrazole-5-carboxamide (70978-04-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 44 percent / conc. HNO₃, conc. H₂SO₄ / -20 °C

2: 60 percent / H₂ / 5percent Pd/C / ethanol

3: pyridine / CH₂Cl₂ / 1 h / 20 °C

With pyridine; sulfuric acid; hydrogen; nitric acid; palladium on activated charcoal; In ethanol; dichloromethane;

DOI:10.1021/jm00154a019

Reference yield:

5-ethyl-2-hydroxy-3-nitroacetophenone (71002-71-6) → N-(3-acetyl-5-ethyl-2-hydroxyphenyl)-2-(4-methoxybenzyl)tetrazole-5-carboxamide (70978-04-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 60 percent / H₂ / 5percent Pd/C / ethanol

2: pyridine / CH₂Cl₂ / 1 h / 20 °C

With pyridine; hydrogen; palladium on activated charcoal; In ethanol; dichloromethane;

DOI:10.1021/jm00154a019

Reference yield:

2-acetyl-6-amino-4-ethylphenol (70977-78-5) + 2-(4-methoxybenzyl)-2H-tetrazole-5-carbonyl chloride (100245-19-0) → N-(3-acetyl-5-ethyl-2-hydroxyphenyl)-2-(4-methoxybenzyl)tetrazole-5-carboxamide (70978-04-0)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃; for 1h; Yield given;

DOI:10.1021/jm00154a019

upstream raw materials:

2-acetyl-6-amino-4-ethylphenol

2-(4-methoxybenzyl)-2H-tetrazole-5-carbonyl chloride

potassium 2-(p-methoxybenzyl)tetrazole-5-carboxylate

3-ethyl-6-hydroxyacetophenone

Downstream raw materials:

N-(3-acetyl-5-ethyl-2-hydroxyphenyl)-1H-tetrazole-5-carboxamide