(1R,2R,3S,4R,5S)-4-(2-iodo-6-(2,2-diphenylethylamino)-9H-purin-9-yl)-2',3'-O-(isopropylidene)bicyclo[3.1.0]hexane

Base Information

Chemical Name:(1R,2R,3S,4R,5S)-4-(2-iodo-6-(2,2-diphenylethylamino)-9H-purin-9-yl)-2',3'-O-(isopropylidene)bicyclo[3.1.0]hexane
CAS No.:1383554-60-6
Molecular Formula:C₂₈H₂₈IN₅O₂
Molecular Weight:593.467
Hs Code.:

Synonyms:(1R,2R,3S,4R,5S)-4-(2-iodo-6-(2,2-diphenylethylamino)-9H-purin-9-yl)-2',3'-O-(isopropylidene)bicyclo[3.1.0]hexane

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Chemical Property of (1R,2R,3S,4R,5S)-4-(2-iodo-6-(2,2-diphenylethylamino)-9H-purin-9-yl)-2',3'-O-(isopropylidene)bicyclo[3.1.0]hexane

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Technology Process of (1R,2R,3S,4R,5S)-4-(2-iodo-6-(2,2-diphenylethylamino)-9H-purin-9-yl)-2',3'-O-(isopropylidene)bicyclo[3.1.0]hexane

There total 2 articles about (1R,2R,3S,4R,5S)-4-(2-iodo-6-(2,2-diphenylethylamino)-9H-purin-9-yl)-2',3'-O-(isopropylidene)bicyclo[3.1.0]hexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1169605-26-8
6-chloro-9-((3aR,3bR,4aS,5R,5aS)-hexahydro-2,2dimethylbicyclo[3.1.0]hex-1⁽⁵⁾-eno[3,2-d] [1,3]dioxol-5-yl)-2-iodo-9H-purine

: 7351-52-2
2,2-Diphenylethylamine hydrochloride

: 1383554-60-6
(1R,2R,3S,4R,5S)-4-(2-iodo-6-(2,2-diphenylethylamino)-9H-purin-9-yl)-2',3'-O-(isopropylidene)bicyclo[3.1.0]hexane

Guidance literature:: With triethylamine; In methanol; at 20 ℃; Inert atmosphere;
DOI:10.1021/ml300107e

Reference yield:

: 1078503-71-5
(3aR,3bR,4aS,5S,5aS)-2,2-dimethylhexahydrocyclopropa[3,4]-cyclopenta[1,2-d][1,3]dioxol-5-ol

: 1383554-60-6
(1R,2R,3S,4R,5S)-4-(2-iodo-6-(2,2-diphenylethylamino)-9H-purin-9-yl)-2',3'-O-(isopropylidene)bicyclo[3.1.0]hexane

Guidance literature:: Multi-step reaction with 2 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 20 °C

2: triethylamine / methanol / 20 °C / Inert atmosphere

With di-isopropyl azodicarboxylate; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; 1: Mitsunobu reaction;
DOI:10.1021/ml300107e

Reference yield:

: 143874-13-9
4-ethynyl-1,2-difluorobenzene

: 1383554-60-6
(1R,2R,3S,4R,5S)-4-(2-iodo-6-(2,2-diphenylethylamino)-9H-purin-9-yl)-2',3'-O-(isopropylidene)bicyclo[3.1.0]hexane

: 1383554-90-2
C₃₆H₃₁F₂N₅O₂

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;
DOI:10.1021/ml300107e