143874-13-9

Basic information

• Product Name: 3,4-DIFLUOROPHENYLACETYLENE
• Synonyms: 3,4-DIFLUOROPHENYLACETYLENE;4-ETHYNYL-1,2-DIFLUORO-BENZENE;Benzene, 4-ethynyl-1,2-difluoro- (9CI);3,4-Difluorophenylacetylene95%;Benzene, 4-ethynyl-1,2-difluoro-;1,2-Difluoro-4-ethynylbenzene;3,4-Difluoro-1-ethynylbenzene
• CAS NO: 143874-13-9
• Molecular Formula: C₈H₄F₂
• Molecular Weight: 138.11
• Product Categories: Aromatics
• Mol File: 143874-13-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 54/2mm
• Flash Point: 7 °C
• Appearance: /
• Density: 1.144 g/mL at 25 °C
• Vapor Pressure: 5.998mmHg at 25°C
• Refractive Index: 1.4902
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 3,4-DIFLUOROPHENYLACETYLENE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-DIFLUOROPHENYLACETYLENE(143874-13-9)
• EPA Substance Registry System: 3,4-DIFLUOROPHENYLACETYLENE(143874-13-9)

Safety Data

• Hazard Codes: F
• Statements: 11
• RIDADR: UN 1993 3/PG 2
• WGK Germany: 3
• Hazardous Substances Data: 143874-13-9(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 143874-13-9 differently. You can refer to the following data:
1. 3,4-DIFLUOROPHENYLACETYLENE is a fundamental building block used in organic synthesis for the preparation of metalated and metal-free tetraalkynyl-substituted phthalocyanines, and 3,5-substituted enones etc.
2. A fundamental building block used in organic synthesis for the preparation of metalated and metal-free tetraalkynyl-substituted phthalocyanines, and 3,5-substituted enones etc.

InChI:InChI=1/C8H4F2/c1-2-6-3-4-7(9)8(10)5-6/h1,3-5H

Upstream product

• 34036-07-2 3,4 difluorobenzaldehyde 
• 159957-01-4 3,4-Difluoro-β,β'-dibromostyrene 
• 348-61-8 1-bromo-3,4-difluorobenzene 
• 866683-38-7 [2-(3,4-difluorophenyl)ethynyl]trimethylsilane 

Downstream Products

• 177577-65-0 1-(3,4-difluorophenyl)-2-[4-(1-trans-pentenyl)phenyl]acetylene 
• 1312797-57-1 C₁₆H₁₄F₂O 
• 1373498-48-6 C₁₆H₁₀F₂O₄ 
• 1373495-88-5 C₁₆H₁₀F₂O₃ 
• 1377273-41-0 (1S,2R,3S,4R,5S)-4-(2-((3,4-difluorophenyl)ethynyl)-6-(methylamino)-9H-purin-9-yl)-2,3-O-isopropylidene-N-methylbicyclo[3.1.0]hexane-1-carboxamide 
• 1377273-65-8 C₃₁H₂₇ClF₂N₆O₃ 
• 1374219-62-1 5-(3,4-difluorobenzyl)-3-(3,4-difluorophenyl)isoxazole 
• 1245447-39-5 C₁₆H₆F₄ 
• 1286239-77-7 3-[4-(3,4-difluorophenyl)-1H-1,2,3-triazol-1-yl]propyl methacrylate 
• 1286239-82-4 3-[4-(3,4-difluorophenyl)-1H-1,2,3-triazol-1-yl]propyl 2,4,4,4-tetrachloro-2-methylbutanoate 

Relevant articles and documents

Discovery and Characterization of Pure RhlR Antagonists against Pseudomonas aeruginosa Infections

Pseudomonas aeruginosa (P. aeruginosa) is an opportunistic human pathogen that forms biofilms and produces virulence factors via quorum sensing (QS). Blocking the QS system in P. aeruginosa is an excellent strategy to reduce biofilm formation and the production of virulence factors. RhlR plays an essential role in the QS system of P. aeruginosa. We synthesized 55 analogues based on the chemical structure of 4-gingerol and evaluated their RhlR inhibitory activities using the cell-based reporter strain assay. Comprehensive structure-activity relationship studies identified the alkynyl ketone 30 as the most potent RhlR antagonist. This compound displayed selective RhlR antagonism over LasR and PqsR, strong inhibition of biofilm formation, and reduced production of virulence factors in P. aeruginosa. Furthermore, the survival rate of Tenebrio molitor larvae treated with 30 in vivo greatly improved. Therefore, compound 30, a pure RhlR antagonist, can be utilized for developing QS-modulating molecules in the control of P. aeruginosa infections.

PYRIDYL DERIVATIVES AND THEIR USE AS MGLU5 RECEPTOR ANTAGONISTS

The present invention is directed toward pyridyl derivatives of formula (I) as antagonists of the mGlu5 receptor. As such the compounds may be useful for treatment or prevention of disorders remedied by antagonism of the mGlu5 receptor, wherein Ar is phenyl or napthyl each of which may be substituted by one or more C1-C4 alkyl, C1-C4 alkoxy, C1-C5 acyl, halo, amino, nitro, cyano, hydroxy, C1-C5 acylamino, C1-C4 alkylsulfonylamino, mono-, di- or trifluorinated C1-C3 alkyl, substituents which may be the same or different and may bear a CONH2, CONHCH3, CON(CH3)2, CO2H, CO2CH3, OCF3, CH2NHCOCH3, CH2NH2, CH2N(CH3)2, CH2CN, CH2OH, CH2NHSO2CH3, CH2N(CH3)(CH2)2 CN, CH2N(CH3)CH(CH3)2, CH2NHCH(CH3)2, CH2NH(CH2)2CH3, CH2NHCO2R4, CH2NHCH2CH3, CH2NHCH3 NHCOC(CH3)2, or N(S(O)2CH3)2 substituent; R1 is hydrogen, halo, R4, CN, C(NOH)R3, C(NO-R4)R3, (CH)2CO2R4 , (CH2)n OR3 , COR3 , CF3,SR4 , S(O)R4, S(O)2R4, COCH2CO2R3 , NHSO2R4 , NHCOR3, C(NOR3)NH2, CH2OCOR3,(CH2)n NH2, CON(CH3)2 (CH2)nNHCO2R4 , CO2R3, CONH2, CSNH2, C(NH)NHOR3, (CH2)nN(CH3)2, or CONHNHCOR3; R2 is 1,2-ethenediyl or 1,2-ethynediyl; R3 is hydrogen or C1-C4 alkyl; R4 is C1-C4 alkyl; and n is 0, 1, 2,3 or 4; or a pharmaceutically acceptable salt thereof, or an N-oxide thereof.