3-(3-BroMopropyl)-2,3-dihydro-2-oxo-1H-benziMidazole-1-carboxylic Acid 1,1-DiMethylethyl Ester

Base Information

Chemical Name:3-(3-BroMopropyl)-2,3-dihydro-2-oxo-1H-benziMidazole-1-carboxylic Acid 1,1-DiMethylethyl Ester
CAS No.:1148017-48-4
Molecular Formula:C₁₅H₁₉BrN₂O₃
Molecular Weight:355.231
Hs Code.:
Mol file:1148017-48-4.mol

Synonyms:tert-butyl 3-(3-bromopropyl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-1-carboxylate

Suppliers and Price of 3-(3-BroMopropyl)-2,3-dihydro-2-oxo-1H-benziMidazole-1-carboxylic Acid 1,1-DiMethylethyl Ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
3-(3-Bromopropyl)-2,3-dihydro-2-oxo-1H-benzimidazole-1-carboxylicAcid1,1-DimethylethylEster
25mg
$ 580.00

Medical Isotopes, Inc.
3-(3-Bromopropyl)-2,3-dihydro-2-oxo-1H-benzimidazole-1-carboxylicAcid1,1-DimethylethylEster
25 mg
$ 1025.00

Total 0 raw suppliers

Chemical Property of 3-(3-BroMopropyl)-2,3-dihydro-2-oxo-1H-benziMidazole-1-carboxylic Acid 1,1-DiMethylethyl Ester

Chemical Property:

Solubility.:DCM, Ethyl Acetate, Methanol

Purity/Quality:: 3-(3-Bromopropyl)-2,3-dihydro-2-oxo-1H-benzimidazole-1-carboxylicAcid1,1-DimethylethylEster ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses 3-(3-Bromopropyl)-2,3-dihydro-2-oxo-1H-benzimidazole-1-carboxylic Acid 1,1-Dimethylethyl Ester is an impurity of Domperidone (D531100), a novel peripheral dopamine receptor antagonist that does not cross the blood-brain barrier and is used as an anti-emetic agent.

Technology Process of 3-(3-BroMopropyl)-2,3-dihydro-2-oxo-1H-benziMidazole-1-carboxylic Acid 1,1-DiMethylethyl Ester

There total 3 articles about 3-(3-BroMopropyl)-2,3-dihydro-2-oxo-1H-benziMidazole-1-carboxylic Acid 1,1-DiMethylethyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 109-64-8
1,3-dibromo-propane

: 161468-45-7
tert‐butyl 2‐oxo‐2,3‐dihydro‐1H‐benzo[d]imidazole‐1‐carboxylate

: 1148017-48-4
tert-butyl 3-(3-bromopropyl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-1-carboxylate

Guidance literature:: With tetrabutylammomium bromide; potassium carbonate; In water; at 80 ℃; for 1h; Inert atmosphere; Microwave irradiation;
DOI:10.1021/acs.jmedchem.5b00874

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1148017-48-4
tert-butyl 3-(3-bromopropyl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

1.2: 24 h / 20 °C / Inert atmosphere

2.1: tetrabutylammomium bromide; potassium carbonate / water / 1 h / 80 °C / Inert atmosphere; Microwave irradiation

With tetrabutylammomium bromide; sodium hydride; potassium carbonate; In water; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.5b00874

Reference yield:

: 615-16-7
1,3-dihydro-2H-benzimidazol-2-one

: 1148017-48-4
tert-butyl 3-(3-bromopropyl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

1.2: 24 h / 20 °C / Inert atmosphere

2.1: tetrabutylammomium bromide; potassium carbonate / water / 1 h / 80 °C / Inert atmosphere; Microwave irradiation

With tetrabutylammomium bromide; sodium hydride; potassium carbonate; In water; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.5b00874