(-)-(2S,5S,1R)-5-methyl-2-(1-methyl-1-phenylethyl)-cyclohexyl (Z)-4,4,4-trifluoro-3-(4-methoxyanilino)-2-methyl-2-butenoate

Base Information

Chemical Name:(-)-(2S,5S,1R)-5-methyl-2-(1-methyl-1-phenylethyl)-cyclohexyl (Z)-4,4,4-trifluoro-3-(4-methoxyanilino)-2-methyl-2-butenoate
CAS No.:445009-18-7
Molecular Formula:C₂₈H₃₄F₃NO₃
Molecular Weight:489.578
Hs Code.:

Synonyms:(-)-(2S,5S,1R)-5-methyl-2-(1-methyl-1-phenylethyl)-cyclohexyl (Z)-4,4,4-trifluoro-3-(4-methoxyanilino)-2-methyl-2-butenoate

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Chemical Property of (-)-(2S,5S,1R)-5-methyl-2-(1-methyl-1-phenylethyl)-cyclohexyl (Z)-4,4,4-trifluoro-3-(4-methoxyanilino)-2-methyl-2-butenoate

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Technology Process of (-)-(2S,5S,1R)-5-methyl-2-(1-methyl-1-phenylethyl)-cyclohexyl (Z)-4,4,4-trifluoro-3-(4-methoxyanilino)-2-methyl-2-butenoate

There total 1 articles about (-)-(2S,5S,1R)-5-methyl-2-(1-methyl-1-phenylethyl)-cyclohexyl (Z)-4,4,4-trifluoro-3-(4-methoxyanilino)-2-methyl-2-butenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 104910-51-2
8-phenylmenthyl propionate

: 75999-66-5
(Z)-2,2,2-trifluoro-N-(4-methoxyphenyl)acetimidoyl chloride

: 445009-18-7
(-)-(2S,5S,1R)-5-methyl-2-(1-methyl-1-phenylethyl)-cyclohexyl (Z)-4,4,4-trifluoro-3-(4-methoxyanilino)-2-methyl-2-butenoate

Guidance literature:: 8-phenylmenthyl propionate; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -50 ℃; for 1.5h;

(Z)-2,2,2-trifluoro-N-(4-methoxyphenyl)acetimidoyl chloride; In tetrahydrofuran; hexane; at -78 ℃; Further stages.;
DOI:10.1021/jo025621k

Reference yield:

: 445009-18-7
(-)-(2S,5S,1R)-5-methyl-2-(1-methyl-1-phenylethyl)-cyclohexyl (Z)-4,4,4-trifluoro-3-(4-methoxyanilino)-2-methyl-2-butenoate

: 445009-32-5
(2S,5S,1R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl (2R,3R)-4,4,4-trifluoro-3-(4-methoxyanilino)-2-methylbutanoate

: 445009-40-5
(2S,5S,1R)-5-methyl-2-(1-methyl-1-phenylethyl)-cyclohexyl (2S,3S)-4,4,4-trifluoro-3-(4-methoxyanilino)-2-methyl-butanoate

Guidance literature:: With sodium tetrahydroborate; zinc(II) iodide; In dichloromethane; at 20 ℃; for 36h;
DOI:10.1021/jo025621k

Reference yield:

: 445009-18-7
(-)-(2S,5S,1R)-5-methyl-2-(1-methyl-1-phenylethyl)-cyclohexyl (Z)-4,4,4-trifluoro-3-(4-methoxyanilino)-2-methyl-2-butenoate

: (2S,3S)-3-(4-methoxyphenylamino)-4,4,4-trifluoro-2-methylbutan-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1: ZnI₂; NaBH₄ / CH₂Cl₂ / 36 h / 20 °C

2: 70 percent / LiAlH₄ / tetrahydrofuran / 2 h / 20 °C

With sodium tetrahydroborate; lithium aluminium tetrahydride; zinc(II) iodide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo025621k