(2S,5S,1R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl (2R,3R)-4,4,4-trifluoro-3-(4-methoxyanilino)-2-methylbutanoate

Base Information

Chemical Name:(2S,5S,1R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl (2R,3R)-4,4,4-trifluoro-3-(4-methoxyanilino)-2-methylbutanoate
CAS No.:445009-32-5
Molecular Formula:C₂₈H₃₆F₃NO₃
Molecular Weight:491.594
Hs Code.:

Synonyms:(2S,5S,1R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl (2R,3R)-4,4,4-trifluoro-3-(4-methoxyanilino)-2-methylbutanoate

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Chemical Property of (2S,5S,1R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl (2R,3R)-4,4,4-trifluoro-3-(4-methoxyanilino)-2-methylbutanoate

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Technology Process of (2S,5S,1R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl (2R,3R)-4,4,4-trifluoro-3-(4-methoxyanilino)-2-methylbutanoate

There total 3 articles about (2S,5S,1R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl (2R,3R)-4,4,4-trifluoro-3-(4-methoxyanilino)-2-methylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 445009-18-7
(-)-(2S,5S,1R)-5-methyl-2-(1-methyl-1-phenylethyl)-cyclohexyl (Z)-4,4,4-trifluoro-3-(4-methoxyanilino)-2-methyl-2-butenoate

: 445009-32-5
(2S,5S,1R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl (2R,3R)-4,4,4-trifluoro-3-(4-methoxyanilino)-2-methylbutanoate

: 445009-40-5
(2S,5S,1R)-5-methyl-2-(1-methyl-1-phenylethyl)-cyclohexyl (2S,3S)-4,4,4-trifluoro-3-(4-methoxyanilino)-2-methyl-butanoate

Guidance literature:: With sodium tetrahydroborate; zinc(II) iodide; In dichloromethane; at 20 ℃; for 36h;
DOI:10.1021/jo025621k

Reference yield:

: 104910-51-2
8-phenylmenthyl propionate

: 445009-32-5
(2S,5S,1R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl (2R,3R)-4,4,4-trifluoro-3-(4-methoxyanilino)-2-methylbutanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: LDA / tetrahydrofuran; hexane / 1.5 h / -50 °C

1.2: 85 percent / tetrahydrofuran; hexane / -78 °C

2.1: ZnI₂; NaBH₄ / CH₂Cl₂ / 36 h / 20 °C

With sodium tetrahydroborate; zinc(II) iodide; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/jo025621k

Reference yield:

: 75999-66-5
(Z)-2,2,2-trifluoro-N-(4-methoxyphenyl)acetimidoyl chloride

: 445009-32-5
(2S,5S,1R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl (2R,3R)-4,4,4-trifluoro-3-(4-methoxyanilino)-2-methylbutanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: LDA / tetrahydrofuran; hexane / 1.5 h / -50 °C

1.2: 85 percent / tetrahydrofuran; hexane / -78 °C

2.1: ZnI₂; NaBH₄ / CH₂Cl₂ / 36 h / 20 °C

With sodium tetrahydroborate; zinc(II) iodide; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/jo025621k