3-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1-benz yl-4-butyl-6-methylpyridin-2(1H)-one

Base Information

Chemical Name:3-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1-benz yl-4-butyl-6-methylpyridin-2(1H)-one
CAS No.:1312938-59-2
Molecular Formula:C₃₁H₃₁N₅O
Molecular Weight:489.62
Hs Code.:

Synonyms:3-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1-benz yl-4-butyl-6-methylpyridin-2(1H)-one

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Chemical Property of 3-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1-benz yl-4-butyl-6-methylpyridin-2(1H)-one

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Technology Process of 3-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1-benz yl-4-butyl-6-methylpyridin-2(1H)-one

There total 6 articles about 3-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1-benz yl-4-butyl-6-methylpyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 1312938-84-3
4'-[(1-benzyl-4-butyl-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]biphenyl-2-carbonitrile

: 1312938-59-2
3-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1-benz yl-4-butyl-6-methylpyridin-2(1H)-one

Guidance literature:: With trimethylsilylazide; di(n-butyl)tin oxide; In toluene; for 16h; Reflux; Inert atmosphere;

Reference yield:

: 33524-79-7
1-benzyl-6-methyl-1,2,3,4-tetrahydropyridine-2,4-dione

: 1312938-59-2
3-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1-benz yl-4-butyl-6-methylpyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine; lithium chloride / N,N-dimethyl-formamide / 20 - 70 °C

2.1: pyridine / dichloromethane / 2 h / 20 °C

2.2: Inert atmosphere

3.1: palladium bis[bis(diphenylphosphino)ferrocene] dichloride / toluene; tetrahydrofuran / 1.5 h / 0 - 90 °C / Inert atmosphere

4.1: di(n-butyl)tin oxide; trimethylsilylazide / toluene / 16 h / Reflux; Inert atmosphere

With pyridine; trimethylsilylazide; di(n-butyl)tin oxide; N-ethyl-N,N-diisopropylamine; lithium chloride; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1312938-83-2
4'-[(1-benzyl-4-hydroxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]biphenyl-2-carbonitrile

: 1312938-59-2
3-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1-benz yl-4-butyl-6-methylpyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / dichloromethane / 2 h / 20 °C

1.2: Inert atmosphere

2.1: palladium bis[bis(diphenylphosphino)ferrocene] dichloride / toluene; tetrahydrofuran / 1.5 h / 0 - 90 °C / Inert atmosphere

3.1: di(n-butyl)tin oxide; trimethylsilylazide / toluene / 16 h / Reflux; Inert atmosphere

With pyridine; trimethylsilylazide; di(n-butyl)tin oxide; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; In tetrahydrofuran; dichloromethane; toluene;