(5-(6-(2-methoxyphenyl)pyrimidin-4-ylamino)-2-(4-methylpiperazin-1-yl)phenyl)methanol

Base Information

Chemical Name:(5-(6-(2-methoxyphenyl)pyrimidin-4-ylamino)-2-(4-methylpiperazin-1-yl)phenyl)methanol
CAS No.:1569982-19-9
Molecular Formula:C₂₃H₂₇N₅O₂
Molecular Weight:405.5
Hs Code.:

Synonyms:(5-(6-(2-methoxyphenyl)pyrimidin-4-ylamino)-2-(4-methylpiperazin-1-yl)phenyl)methanol

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Chemical Property of (5-(6-(2-methoxyphenyl)pyrimidin-4-ylamino)-2-(4-methylpiperazin-1-yl)phenyl)methanol

Chemical Property:

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Technology Process of (5-(6-(2-methoxyphenyl)pyrimidin-4-ylamino)-2-(4-methylpiperazin-1-yl)phenyl)methanol

There total 6 articles about (5-(6-(2-methoxyphenyl)pyrimidin-4-ylamino)-2-(4-methylpiperazin-1-yl)phenyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1569986-19-1
5-[6-(2-methoxy-phenyl)-pyrimidin-4-ylamino]-2-(4-methyl-piperazin-1-yl)-benzoic acid ethyl ester

: 1569982-19-9
(5-(6-(2-methoxyphenyl)pyrimidin-4-ylamino)-2-(4-methylpiperazin-1-yl)phenyl)methanol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield:

: 5720-06-9
2-Methoxyphenylboronic acid

: 1569982-19-9
(5-(6-(2-methoxyphenyl)pyrimidin-4-ylamino)-2-(4-methylpiperazin-1-yl)phenyl)methanol

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; 1,2-dimethoxyethane / 2 h / Inert atmosphere; Reflux

2: hydrogenchloride / ethyl acetate; isopropyl alcohol / 5 h / Reflux

3: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In tetrahydrofuran; 1,2-dimethoxyethane; water; ethyl acetate; isopropyl alcohol;

Reference yield:

: 16588-17-3
ethyl ester of 2-chloro-5-nitrobenzoic acid

: 1569982-19-9
(5-(6-(2-methoxyphenyl)pyrimidin-4-ylamino)-2-(4-methylpiperazin-1-yl)phenyl)methanol

Guidance literature:: Multi-step reaction with 4 steps

1: acetonitrile / 24 h / 20 °C

2: tin(II) chloride dihdyrate; hydrogenchloride / ethanol / 72 h / 20 °C

3: hydrogenchloride / ethyl acetate; isopropyl alcohol / 5 h / Reflux

4: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; tin(II) chloride dihdyrate; In tetrahydrofuran; ethanol; ethyl acetate; isopropyl alcohol; acetonitrile;