2,3-bis(methoxycarbonyl)-5(E)-<<1,2-bis(methoxycarbonyl)vinyl>thio>-7,7-dimethyl-7,8-dihydro-1',3'-dibenzylbenzothiopyran-4-spiro-2'-imidazolidine

Base Information

• Chemical Name: 2,3-bis(methoxycarbonyl)-5(E)-<<1,2-bis(methoxycarbonyl)vinyl>thio>-7,7-dimethyl-7,8-dihydro-1',3'-dibenzylbenzothiopyran-4-spiro-2'-imidazolidine
• CAS No.: 135192-56-2
• Molecular Formula: C₃₇H₄₀N₂O₈S₂
• Molecular Weight: 704.865
• Mol file: 135192-56-2.mol

Synonyms:2,3-bis(methoxycarbonyl)-5(E)-<<1,2-bis(methoxycarbonyl)vinyl>thio>-7,7-dimethyl-7,8-dihydro-1',3'-dibenzylbenzothiopyran-4-spiro-2'-imidazolidine

Chemical Property of 2,3-bis(methoxycarbonyl)-5(E)-<<1,2-bis(methoxycarbonyl)vinyl>thio>-7,7-dimethyl-7,8-dihydro-1',3'-dibenzylbenzothiopyran-4-spiro-2'-imidazolidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,3-bis(methoxycarbonyl)-5(E)-<<1,2-bis(methoxycarbonyl)vinyl>thio>-7,7-dimethyl-7,8-dihydro-1',3'-dibenzylbenzothiopyran-4-spiro-2'-imidazolidine

There total 1 articles about 2,3-bis(methoxycarbonyl)-5(E)-<<1,2-bis(methoxycarbonyl)vinyl>thio>-7,7-dimethyl-7,8-dihydro-1',3'-dibenzylbenzothiopyran-4-spiro-2'-imidazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

2-(1,3-Dibenzyl-imidazolidin-2-yl)-3-mercapto-5,5-dimethyl-cyclohex-2-enethione + dimethyl acetylenedicarboxylate (762-42-5) → 2,3,5,6-tetrakis(methoxycarbonyl)-8H-8,8-dimethyl-1,4-dithiaphenalene (135192-60-8) + C37H40N2O8S2 (135192-57-3) + 2,3-bis(methoxycarbonyl)-5(E)-<<1,2-bis(methoxycarbonyl)vinyl>thio>-7,7-dimethyl-7,8-dihydro-1',3'-dibenzylbenzothiopyran-4-spiro-2'-imidazolidine (135192-56-2)

Guidance literature:

In toluene; Ambient temperature;

DOI:10.1021/jo00016a021

Reference yield: 37.0%

2,3-bis(methoxycarbonyl)-5(E)-<<1,2-bis(methoxycarbonyl)vinyl>thio>-7,7-dimethyl-7,8-dihydro-1',3'-dibenzylbenzothiopyran-4-spiro-2'-imidazolidine (135192-56-2) → 2,3-bis(methoxycarbonyl)-4-amino>-5(E)-<<1,2-bis(methoxycarbonyl)vinyl>thio>-7,7-dimethyl-7H-benzothiopyran (135192-67-5)

Guidance literature:

With hydrogenchloride; In ethanol; for 18h; Ambient temperature;

DOI:10.1021/jo00016a021

Reference yield:

2,3-bis(methoxycarbonyl)-5(E)-<<1,2-bis(methoxycarbonyl)vinyl>thio>-7,7-dimethyl-7,8-dihydro-1',3'-dibenzylbenzothiopyran-4-spiro-2'-imidazolidine (135192-56-2) → 2,3-bis(methoxycarbonyl)-4-amino>-5(E)-<<1,2-bis(methoxycarbonyl)vinyl>thio>-7,7-dimethyl-7H-benzothiopyran (135192-67-5) + 2,3-bis(methoxycarbonyl)-5(E)-<<1,2-bis(methoxycarbonyl)vinyl>thio>-7,7-dimethyl-7,8-dihydrobenzothiopyran-4-one (135225-05-7) + 5-((E)-1,2-Bis-methoxycarbonyl-vinylsulfanyl)-4-hydroxy-7,7-dimethyl-7H-thiochromene-2,3-dicarboxylic acid dimethyl ester (135192-71-1)

Guidance literature:

With hydrogenchloride; water; In methanol; for 52h; Ambient temperature; also Z-isomer;

DOI:10.1021/jo00016a021

upstream raw materials:

dimethyl acetylenedicarboxylate

Downstream raw materials:

2,3-bis(methoxycarbonyl)-4-amino>-5(E)-<<1,2-bis(methoxycarbonyl)vinyl>thio>-7,7-dimethyl-7H-benzothiopyran

2,3-bis(methoxycarbonyl)-5(E)-<<1,2-bis(methoxycarbonyl)vinyl>thio>-7,7-dimethyl-7,8-dihydrobenzothiopyran-4-one

5-((E)-1,2-Bis-methoxycarbonyl-vinylsulfanyl)-4-hydroxy-7,7-dimethyl-7H-thiochromene-2,3-dicarboxylic acid dimethyl ester