(S)-2-(1-(4-((1-(2-fluoro-5-methoxyphenyl)piperidin-4-yl)oxy)phenyl)pyrrolidin-2-yl)acetonitrile

Base Information

Chemical Name:(S)-2-(1-(4-((1-(2-fluoro-5-methoxyphenyl)piperidin-4-yl)oxy)phenyl)pyrrolidin-2-yl)acetonitrile
CAS No.:1610034-62-2
Molecular Formula:C₂₄H₂₈FN₃O₂
Molecular Weight:409.504
Hs Code.:

Synonyms:(S)-2-(1-(4-((1-(2-fluoro-5-methoxyphenyl)piperidin-4-yl)oxy)phenyl)pyrrolidin-2-yl)acetonitrile

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Chemical Property of (S)-2-(1-(4-((1-(2-fluoro-5-methoxyphenyl)piperidin-4-yl)oxy)phenyl)pyrrolidin-2-yl)acetonitrile

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Technology Process of (S)-2-(1-(4-((1-(2-fluoro-5-methoxyphenyl)piperidin-4-yl)oxy)phenyl)pyrrolidin-2-yl)acetonitrile

There total 4 articles about (S)-2-(1-(4-((1-(2-fluoro-5-methoxyphenyl)piperidin-4-yl)oxy)phenyl)pyrrolidin-2-yl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

: 1610034-61-1
(S)-2-(1-(4-(piperidin-4-yloxy)phenyl)pyrrolidin-2-yl)acetonitrile

: 2-bromo-1-fluoro-4-methoxy-benzene

: 1610034-62-2
(S)-2-(1-(4-((1-(2-fluoro-5-methoxyphenyl)piperidin-4-yl)oxy)phenyl)pyrrolidin-2-yl)acetonitrile

Guidance literature:: (S)-2-(1-(4-(piperidin-4-yloxy)phenyl)pyrrolidin-2-yl)acetonitrile; 2-bromo-1-fluoro-4-methoxy-benzene; With potassium tert-butylate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In N,N-dimethyl-formamide; for 0.333333h; Inert atmosphere;

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; at 100 ℃; for 1h; Microwave irradiation;

Reference yield:

: 118811-07-7
tert-butyl 4-(tosyloxy)piperidin-1-carboxylate

: 1610034-62-2
(S)-2-(1-(4-((1-(2-fluoro-5-methoxyphenyl)piperidin-4-yl)oxy)phenyl)pyrrolidin-2-yl)acetonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 °C

1.2: 3 h / 80 °C

2.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

3.1: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; potassium tert-butylate / N,N-dimethyl-formamide / 0.33 h / Inert atmosphere

3.2: 1 h / 100 °C / Microwave irradiation

With potassium tert-butylate; sodium hydride; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1610034-60-0
(S)-tert-butyl 4-(4-(2-(cyanomethyl)pyrrolidin-1-yl)phenoxy)piperidine-1-carboxylate

: 1610034-62-2
(S)-2-(1-(4-((1-(2-fluoro-5-methoxyphenyl)piperidin-4-yl)oxy)phenyl)pyrrolidin-2-yl)acetonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

2.1: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; potassium tert-butylate / N,N-dimethyl-formamide / 0.33 h / Inert atmosphere

2.2: 1 h / 100 °C / Microwave irradiation

With potassium tert-butylate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;