1-BOC-4-(tosyloxy)piperidine

Base Information

• Chemical Name: 1-BOC-4-(tosyloxy)piperidine
• CAS No.: 118811-07-7
• Molecular Formula: C17H25NO5S
• Molecular Weight: 355.455
• Hs Code.: 2933399090
• European Community (EC) Number: 675-823-7
• DSSTox Substance ID: DTXSID70577673
• Nikkaji Number: J1.690.530E
• Wikidata: Q72509266
• Mol file: 118811-07-7.mol

Synonyms:1-BOC-4-(tosyloxy)piperidine;118811-07-7;4-(Toluene-4-sulfonyloxy)-piperidine-1-carboxylic acid tert-butyl ester;tert-butyl 4-(tosyloxy)piperidine-1-carboxylate;4-(Toluene-4-sulfonyloxy)piperidine-1-carboxylic acid tert-butyl ester;N-Boc-4-piperidyl p-Methylbenzenesulfonate;1-(tert-Butoxycarbonyl)-4-(p-toluenesulfonyloxy)piperidine;MFCD06796535;tert-butyl 4-(4-methylphenyl)sulfonyloxypiperidine-1-carboxylate;tert-butyl 4-[(4-methylbenzenesulfonyl)oxy]piperidine-1-carboxylate;tert-Butyl 4-{[(4-methylphenyl)sulfonyl]oxy}piperidine-1-carboxylate;1-Boc-4-tosyloxypiperidine;tert-butyl 4-(((4-methylphenyl)sulfonyl)oxy)piperidine-1-carboxylate;1-boc-4-(toluene-4-sulfonyloxy)-piperidine;SCHEMBL184777;DTXSID70577673;IKOMRHLHPZAEMV-UHFFFAOYSA-N;BCP23250;AKOS015836936;AB29430;CS-W000336;BP-10255;DS-13055;SY035513;N-Boc-4-(Toluene-4-Sulfonyloxy)piperidine;AM20020265;B4516;EN300-55946;tert-Butyl 4-Tosyloxypiperidine-1-carboxylate;4-Tosyloxypiperidine-1-carboxylic Acid tert-Butyl Es;t-butyl 4-(toluene-4-sulfonyloxy)piperidine-1-carboxylate;tert-Butyl 4-(p-Toluenesulfonyloxy)piperidine-1-carboxylate;tert-butyl 4-(toluene-4-sulfonyloxy)piperidine-1-carboxylate;tert-butyl 4-(toluene-4-sulphonyloxy)-piperidine-1-carboxylate;tert.butyl 4-(toluene-4-sulphonyloxy)-piperidine-1-carboxylate;Tert-butyl 4-[(4-methylphenyl)sulfonyl]oxy-1-piperidinecarboxylate;tert. butyl 4-(toluene-4-sulphonyloxy)-piperidine-1-carboxylate;4-(p-Toluenesulfonyloxy)piperidine-1-carboxylic Acid tert-Butyl Ester;tert-Butyl 4-[(4-methylbenzene-1-sulfonyl)oxy]piperidine-1-carboxylate;1,1-Dimethylethyl 4-{[(4-methylphenyl)sulfonyl]oxy}-1-piperidinecarboxylate

Chemical Property of 1-BOC-4-(tosyloxy)piperidine

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 96.0 to 100.0 °C
• Refractive Index: 1.553
• Boiling Point: 475.282 °C at 760 mmHg
• PKA: -2.97±0.40(Predicted)
• Flash Point: 241.242 °C
• PSA: 81.29000
• Density: 1.237 g/cm³
• LogP: 4.11850
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility.: soluble in Methanol
• XLogP3: 3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 5
• Exact Mass: 355.14534407
• Heavy Atom Count: 24
• Complexity: 518

Purity/Quality:

97% ^*data from raw suppliers

1-boc-4-(Tosyloxy)piperidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)S(=O)(=O)OC2CCN(CC2)C(=O)OC(C)(C)C

Technology Process of 1-BOC-4-(tosyloxy)piperidine

There total 6 articles about 1-BOC-4-(tosyloxy)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

p-toluenesulfonyl chloride (98-59-9) + t-butyl 4-hydroxy piperidine-1-carboxylate (109384-19-2) → tert-butyl 4-(tosyloxy)piperidin-1-carboxylate (118811-07-7)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 20h;

Reference yield: 60.0%

tert-butyl 2-hydroxypiperidine-1-carboxylate (86953-81-3) + p-toluenesulfonyl chloride (98-59-9) → tert-butyl 4-(tosyloxy)piperidin-1-carboxylate (118811-07-7)

Guidance literature:

In pyridine; cyclohexane; water; ethyl acetate;

Reference yield: 51.0%

1-(1,1-dimethylethyl)-4-piperidinol (5382-30-9) + p-toluenesulfonyl chloride (98-59-9) → tert-butyl 4-(tosyloxy)piperidin-1-carboxylate (118811-07-7)

Guidance literature:

With pyridine; In chloroform; at 20 ℃;

upstream raw materials:

p-toluenesulfonyl chloride

t-butyl 4-hydroxy piperidine-1-carboxylate

tert-butyl 2-hydroxypiperidine-1-carboxylate

di-tert-butyl dicarbonate

Downstream raw materials:

C₁₈H₂₄ClNO₅

tert-butyl 4-[2-chloro-5-methoxy-4-(methoxycarbonyl)phenoxy]piperidine-1-carboxylate

C₁₉H₂₇NO₅

C₃₁H₃₇Cl₃N₄O₆