(S)-methyl 2-(4-(hydroxymethyl)-6-methylpyrimidin-2-yloxy)-3-methoxy-3,3-diphenylpropanoate

Base Information

Chemical Name:(S)-methyl 2-(4-(hydroxymethyl)-6-methylpyrimidin-2-yloxy)-3-methoxy-3,3-diphenylpropanoate
CAS No.:1106685-63-5
Molecular Formula:C₂₃H₂₄N₂O₅
Molecular Weight:408.454
Hs Code.:

Synonyms:(S)-methyl 2-(4-(hydroxymethyl)-6-methylpyrimidin-2-yloxy)-3-methoxy-3,3-diphenylpropanoate

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Chemical Property of (S)-methyl 2-(4-(hydroxymethyl)-6-methylpyrimidin-2-yloxy)-3-methoxy-3,3-diphenylpropanoate

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Technology Process of (S)-methyl 2-(4-(hydroxymethyl)-6-methylpyrimidin-2-yloxy)-3-methoxy-3,3-diphenylpropanoate

There total 1 articles about (S)-methyl 2-(4-(hydroxymethyl)-6-methylpyrimidin-2-yloxy)-3-methoxy-3,3-diphenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.6%

: 1106685-62-4
(S)-methyl 2-(4-formyl-6-methylpyrimidin-2-yloxy)-3-rnethoxy-3,3-diphenylpropanoate

: 1106685-63-5
(S)-methyl 2-(4-(hydroxymethyl)-6-methylpyrimidin-2-yloxy)-3-methoxy-3,3-diphenylpropanoate

Guidance literature:: With sodium tetrahydroborate; In methanol; for 3h;

Reference yield: 80.0%

: 1106685-63-5
(S)-methyl 2-(4-(hydroxymethyl)-6-methylpyrimidin-2-yloxy)-3-methoxy-3,3-diphenylpropanoate

: 1106685-66-8,1106685-84-0
4-Hydroxymethylambrisentan

Guidance literature:: (S)-methyl 2-(4-(hydroxymethyl)-6-methylpyrimidin-2-yloxy)-3-methoxy-3,3-diphenylpropanoate; With sodium hydroxide; water; In methanol; for 2h; Heating / reflux;

With sulfuric acid; In water; pH=2 - 3;

Reference yield: 69.0%

: 1106685-63-5
(S)-methyl 2-(4-(hydroxymethyl)-6-methylpyrimidin-2-yloxy)-3-methoxy-3,3-diphenylpropanoate

: 100-39-0
benzyl bromide

: 1106685-69-1
(S)-methyl 2-(4-(benzyloxymethyl)-6-methylpyrimidin-2-yloxy)-3-methoxy-3,3-diphenylpropanoate

Guidance literature:: (S)-methyl 2-(4-(hydroxymethyl)-6-methylpyrimidin-2-yloxy)-3-methoxy-3,3-diphenylpropanoate; With lithium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; at 0 ℃; for 0.5h;

benzyl bromide; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 12h;