(Z)-2-bromo-N-((1R,5R)-5-isopropyl-2-methylcyclohex-2-enyl)-6-(4-methoxybenzyloxy)-N-methylhex-2-enamide

Base Information

Chemical Name:(Z)-2-bromo-N-((1R,5R)-5-isopropyl-2-methylcyclohex-2-enyl)-6-(4-methoxybenzyloxy)-N-methylhex-2-enamide
CAS No.:1561029-84-2
Molecular Formula:C₂₅H₃₆BrNO₃
Molecular Weight:478.47
Hs Code.:

Synonyms:(Z)-2-bromo-N-((1R,5R)-5-isopropyl-2-methylcyclohex-2-enyl)-6-(4-methoxybenzyloxy)-N-methylhex-2-enamide

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Chemical Property of (Z)-2-bromo-N-((1R,5R)-5-isopropyl-2-methylcyclohex-2-enyl)-6-(4-methoxybenzyloxy)-N-methylhex-2-enamide

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Technology Process of (Z)-2-bromo-N-((1R,5R)-5-isopropyl-2-methylcyclohex-2-enyl)-6-(4-methoxybenzyloxy)-N-methylhex-2-enamide

There total 10 articles about (Z)-2-bromo-N-((1R,5R)-5-isopropyl-2-methylcyclohex-2-enyl)-6-(4-methoxybenzyloxy)-N-methylhex-2-enamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1561029-79-5
(1R,5R)-5-isopropyl-N,2-dimethylcyclohex-2-enamine

: 1561029-81-9
(Z)-2-bromo-6-(4-methoxybenzyloxy)hex-2-enoic acid

: 1561029-84-2
(Z)-2-bromo-N-((1R,5R)-5-isopropyl-2-methylcyclohex-2-enyl)-6-(4-methoxybenzyloxy)-N-methylhex-2-enamide

Guidance literature:: With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; In dichloromethane; at 20 ℃; for 24h; Inert atmosphere;
DOI:10.1021/ol403609c

Reference yield:

: C₁₂H₁₈Cl₃NO

: 1561029-84-2
(Z)-2-bromo-N-((1R,5R)-5-isopropyl-2-methylcyclohex-2-enyl)-6-(4-methoxybenzyloxy)-N-methylhex-2-enamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / 5,5-dimethyl-1,3-cyclohexadiene / 6 h / Inert atmosphere; Reflux

2: sodium carbonate / N,N-dimethyl-formamide / 4 h / 150 °C / Inert atmosphere

3: lithium aluminium tetrahydride / tetrahydrofuran / 6 h / 0 - 60 °C / Inert atmosphere

4: triethylamine; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride / dichloromethane / 24 h / 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; sodium carbonate; potassium carbonate; triethylamine; In tetrahydrofuran; 5,5-dimethyl-1,3-cyclohexadiene; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol403609c

Reference yield:

: 1561030-08-7
(Z)-ethyl 2-bromo-6-(4-methoxybenzyloxy)hex-2-enoate

: 1561029-84-2
(Z)-2-bromo-N-((1R,5R)-5-isopropyl-2-methylcyclohex-2-enyl)-6-(4-methoxybenzyloxy)-N-methylhex-2-enamide

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide; water / methanol / 12 h / 20 °C / Inert atmosphere

2: triethylamine; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride / dichloromethane / 24 h / 20 °C / Inert atmosphere

With water; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; lithium hydroxide; In methanol; dichloromethane;
DOI:10.1021/ol403609c