Technology Process of (Z)-2-bromo-6-(4-methoxybenzyloxy)hex-2-enoic acid
There total 4 articles about (Z)-2-bromo-6-(4-methoxybenzyloxy)hex-2-enoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
water; lithium hydroxide;
In
methanol;
at 20 ℃;
for 12h;
Inert atmosphere;
DOI:10.1021/ol403609c
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 °C / Inert atmosphere
1.2: 1 h / -78 - 25 °C / Inert atmosphere
2.1: sodium hydride; bromine / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere
2.2: 0.5 h / -78 °C / Inert atmosphere
3.1: lithium hydroxide; water / methanol / 12 h / 20 °C / Inert atmosphere
With
oxalyl dichloride; water; bromine; sodium hydride; dimethyl sulfoxide; lithium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane;
2.1: |Horner-Wadsworth-Emmons Olefination / 2.2: |Horner-Wadsworth-Emmons Olefination;
DOI:10.1021/ol403609c
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydride; tetra-(n-butyl)ammonium iodide / tetrahydrofuran / Inert atmosphere
2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 °C / Inert atmosphere
2.2: 1 h / -78 - 25 °C / Inert atmosphere
3.1: sodium hydride; bromine / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere
3.2: 0.5 h / -78 °C / Inert atmosphere
4.1: lithium hydroxide; water / methanol / 12 h / 20 °C / Inert atmosphere
With
oxalyl dichloride; water; bromine; tetra-(n-butyl)ammonium iodide; sodium hydride; dimethyl sulfoxide; lithium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane;
3.1: |Horner-Wadsworth-Emmons Olefination / 3.2: |Horner-Wadsworth-Emmons Olefination;
DOI:10.1021/ol403609c
