(1R,5S,6S,7R,9S)-7-Methoxy-3-oxo-9-(toluene-4-sulfonyloxymethyl)-2-oxa-bicyclo[3.2.2]nonane-6-carboxylic acid methyl ester

Base Information

Chemical Name:(1R,5S,6S,7R,9S)-7-Methoxy-3-oxo-9-(toluene-4-sulfonyloxymethyl)-2-oxa-bicyclo[3.2.2]nonane-6-carboxylic acid methyl ester
CAS No.:871938-46-4
Molecular Formula:C₁₉H₂₄O₈S
Molecular Weight:412.461
Hs Code.:

Synonyms:(1R,5S,6S,7R,9S)-7-Methoxy-3-oxo-9-(toluene-4-sulfonyloxymethyl)-2-oxa-bicyclo[3.2.2]nonane-6-carboxylic acid methyl ester

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Chemical Property of (1R,5S,6S,7R,9S)-7-Methoxy-3-oxo-9-(toluene-4-sulfonyloxymethyl)-2-oxa-bicyclo[3.2.2]nonane-6-carboxylic acid methyl ester

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Technology Process of (1R,5S,6S,7R,9S)-7-Methoxy-3-oxo-9-(toluene-4-sulfonyloxymethyl)-2-oxa-bicyclo[3.2.2]nonane-6-carboxylic acid methyl ester

There total 5 articles about (1R,5S,6S,7R,9S)-7-Methoxy-3-oxo-9-(toluene-4-sulfonyloxymethyl)-2-oxa-bicyclo[3.2.2]nonane-6-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (1S,2R,3S,4S,7S)-7-Benzyloxymethyl-3-(fluoro-dimethyl-silanyl)-5-oxo-bicyclo[2.2.2]octane-2-carboxylic acid methyl ester

: 871938-46-4
(1R,5S,6S,7R,9S)-7-Methoxy-3-oxo-9-(toluene-4-sulfonyloxymethyl)-2-oxa-bicyclo[3.2.2]nonane-6-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: H₂ / Pd/C / ethyl acetate / 30 h / 760 Torr

2: pyridine; 4-dimethylaminopyridine / CH₂Cl₂ / 10 h / Heating

3: m-chloroperbenzoic acid; Na₂PO₄ / CH₂Cl₂ / 15 h / 20 °C

4: Ag₂O; CaSO₄ / 20 h

With pyridine; dmap; calcium sulfate; hydrogen; 3-chloro-benzenecarboperoxoic acid; silver(l) oxide; palladium on activated charcoal; In dichloromethane; ethyl acetate;
DOI:10.1021/ja055744x

Reference yield:

: 871938-43-1
(1S,2R,3S,4S,7S)-7-Benzyloxymethyl-3-(furan-2-yl-dimethyl-silanyl)-5-oxo-bicyclo[2.2.2]octane-2-carboxylic acid methyl ester

: 871938-46-4
(1R,5S,6S,7R,9S)-7-Methoxy-3-oxo-9-(toluene-4-sulfonyloxymethyl)-2-oxa-bicyclo[3.2.2]nonane-6-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: tetrabutylammonium fluoride / tetrahydrofuran / 0.03 h / 20 °C

2: H₂ / Pd/C / ethyl acetate / 30 h / 760 Torr

3: pyridine; 4-dimethylaminopyridine / CH₂Cl₂ / 10 h / Heating

4: m-chloroperbenzoic acid; Na₂PO₄ / CH₂Cl₂ / 15 h / 20 °C

5: Ag₂O; CaSO₄ / 20 h

With pyridine; dmap; calcium sulfate; tetrabutyl ammonium fluoride; hydrogen; 3-chloro-benzenecarboperoxoic acid; silver(l) oxide; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1021/ja055744x

Reference yield:

: 871938-44-2
(1S,2R,3S,4S,7S)-3-(Fluoro-dimethyl-silanyl)-7-hydroxymethyl-5-oxo-bicyclo[2.2.2]octane-2-carboxylic acid methyl ester

: 871938-46-4
(1R,5S,6S,7R,9S)-7-Methoxy-3-oxo-9-(toluene-4-sulfonyloxymethyl)-2-oxa-bicyclo[3.2.2]nonane-6-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine; 4-dimethylaminopyridine / CH₂Cl₂ / 10 h / Heating

2: m-chloroperbenzoic acid; Na₂PO₄ / CH₂Cl₂ / 15 h / 20 °C

3: Ag₂O; CaSO₄ / 20 h

With pyridine; dmap; calcium sulfate; 3-chloro-benzenecarboperoxoic acid; silver(l) oxide; In dichloromethane;
DOI:10.1021/ja055744x