2-{5-[1-(3-cyclobutoxy-4-difluoromethoxy-phenyl)-2-pyridin-4-yl-ethyl]-thiazol-2-yl}-1,1,1,3,3,3-hexafluoro-propan-2-ol

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Chemical Name:2-{5-[1-(3-cyclobutoxy-4-difluoromethoxy-phenyl)-2-pyridin-4-yl-ethyl]-thiazol-2-yl}-1,1,1,3,3,3-hexafluoro-propan-2-ol
CAS No.:362718-59-0
Molecular Formula:C₂₄H₂₀F₈N₂O₃S
Molecular Weight:568.488
Hs Code.:

Synonyms:2-{5-[1-(3-cyclobutoxy-4-difluoromethoxy-phenyl)-2-pyridin-4-yl-ethyl]-thiazol-2-yl}-1,1,1,3,3,3-hexafluoro-propan-2-ol

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Chemical Property of 2-{5-[1-(3-cyclobutoxy-4-difluoromethoxy-phenyl)-2-pyridin-4-yl-ethyl]-thiazol-2-yl}-1,1,1,3,3,3-hexafluoro-propan-2-ol

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Technology Process of 2-{5-[1-(3-cyclobutoxy-4-difluoromethoxy-phenyl)-2-pyridin-4-yl-ethyl]-thiazol-2-yl}-1,1,1,3,3,3-hexafluoro-propan-2-ol

There total 6 articles about 2-{5-[1-(3-cyclobutoxy-4-difluoromethoxy-phenyl)-2-pyridin-4-yl-ethyl]-thiazol-2-yl}-1,1,1,3,3,3-hexafluoro-propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-(2-(3-cyclobutoxy-4-difluoromethoxy-phenyl)-2-{2-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-thiazol-5-yl}-ethyl)-pyridine

: 362718-59-0
2-{5-[1-(3-cyclobutoxy-4-difluoromethoxy-phenyl)-2-pyridin-4-yl-ethyl]-thiazol-2-yl}-1,1,1,3,3,3-hexafluoro-propan-2-ol

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 1h;
DOI:10.1021/jm0204542

Reference yield:

: 362718-79-4
1,1,1,3,3,3-hexafluoro-2-(1,3-thiazol-2-yl)propan-2-ol

: 362718-59-0
2-{5-[1-(3-cyclobutoxy-4-difluoromethoxy-phenyl)-2-pyridin-4-yl-ethyl]-thiazol-2-yl}-1,1,1,3,3,3-hexafluoro-propan-2-ol

Guidance literature:: Multi-step reaction with 6 steps

1.1: 100 percent / diisopropylethylamine / CH₂Cl₂ / 48 h / 20 °C

2.1: n-BuLi / diethyl ether; hexane / 1 h / -78 °C

2.2: 90 percent / diethyl ether; hexane / 1 h / -78 °C

3.1: pyridine; SOBr₂ / toluene / 0.17 h / 20 °C

4.1: NaHMDS / tetrahydrofuran; hexamethylphosphoric acid triamide / 0.75 h / 20 °C

4.2: tetrahydrofuran; hexamethylphosphoric acid triamide / 15 h / 20 °C

5.1: 436 mg / aq. LiOH / tetrahydrofuran; methanol / 4 h / Heating

6.1: 277 mg / TFA / CH₂Cl₂ / 1 h

With pyridine; lithium hydroxide; sulfurous dibromide; n-butyllithium; sodium hexamethyldisilazane; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; hexane; dichloromethane; toluene;
DOI:10.1021/jm0204542

Reference yield:

: 362718-80-7
2-{1-trifluoromethyl-1-[(2-trimethylsilylethoxy)methoxy]-2,2,2-trifluoroethyl}thiazole

: 362718-59-0
2-{5-[1-(3-cyclobutoxy-4-difluoromethoxy-phenyl)-2-pyridin-4-yl-ethyl]-thiazol-2-yl}-1,1,1,3,3,3-hexafluoro-propan-2-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-BuLi / diethyl ether; hexane / 1 h / -78 °C

1.2: 90 percent / diethyl ether; hexane / 1 h / -78 °C

2.1: pyridine; SOBr₂ / toluene / 0.17 h / 20 °C

3.1: NaHMDS / tetrahydrofuran; hexamethylphosphoric acid triamide / 0.75 h / 20 °C

3.2: tetrahydrofuran; hexamethylphosphoric acid triamide / 15 h / 20 °C

4.1: 436 mg / aq. LiOH / tetrahydrofuran; methanol / 4 h / Heating

5.1: 277 mg / TFA / CH₂Cl₂ / 1 h

With pyridine; lithium hydroxide; sulfurous dibromide; n-butyllithium; sodium hexamethyldisilazane; trifluoroacetic acid; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; hexane; dichloromethane; toluene;
DOI:10.1021/jm0204542