5-[bromo-(3-cyclobutoxy-4-difluoromethoxy-phenyl)-methyl]-2-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-thiazole

Base Information

Chemical Name:5-[bromo-(3-cyclobutoxy-4-difluoromethoxy-phenyl)-methyl]-2-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-thiazole
CAS No.:362719-53-7
Molecular Formula:C₂₄H₂₈BrF₈NO₄SSi
Molecular Weight:686.533
Hs Code.:

5-[bromo-(3-cyclobutoxy-4-difluoromethoxy-phenyl)-methyl]-2-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-thiazole

Synonyms:5-[bromo-(3-cyclobutoxy-4-difluoromethoxy-phenyl)-methyl]-2-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-thiazole

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Chemical Property of 5-[bromo-(3-cyclobutoxy-4-difluoromethoxy-phenyl)-methyl]-2-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-thiazole

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Technology Process of 5-[bromo-(3-cyclobutoxy-4-difluoromethoxy-phenyl)-methyl]-2-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-thiazole

There total 3 articles about 5-[bromo-(3-cyclobutoxy-4-difluoromethoxy-phenyl)-methyl]-2-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 362719-51-5
(+/-)-[(3-cyclobutyloxy-4-difluoromethoxy)phenyl]{2-[(1-trifluoromethyl-1-(2-trimethylsilylethoxy)methoxy)-2,2,2-trifluoro]ethylthiazol-5-yl}methanol

: 362719-53-7
5-[bromo-(3-cyclobutoxy-4-difluoromethoxy-phenyl)-methyl]-2-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-thiazole

Guidance literature:: With pyridine; sulfurous dibromide; In toluene; at 20 ℃; for 0.166667h;
DOI:10.1021/jm0204542

Reference yield:

: 362718-79-4
1,1,1,3,3,3-hexafluoro-2-(1,3-thiazol-2-yl)propan-2-ol

: 362719-53-7
5-[bromo-(3-cyclobutoxy-4-difluoromethoxy-phenyl)-methyl]-2-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-thiazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: 100 percent / diisopropylethylamine / CH₂Cl₂ / 48 h / 20 °C

2.1: n-BuLi / diethyl ether; hexane / 1 h / -78 °C

2.2: 90 percent / diethyl ether; hexane / 1 h / -78 °C

3.1: pyridine; SOBr₂ / toluene / 0.17 h / 20 °C

With pyridine; sulfurous dibromide; n-butyllithium; N-ethyl-N,N-diisopropylamine; In diethyl ether; hexane; dichloromethane; toluene;
DOI:10.1021/jm0204542

Reference yield:

: 362718-80-7
2-{1-trifluoromethyl-1-[(2-trimethylsilylethoxy)methoxy]-2,2,2-trifluoroethyl}thiazole

: 362719-53-7
5-[bromo-(3-cyclobutoxy-4-difluoromethoxy-phenyl)-methyl]-2-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-thiazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-BuLi / diethyl ether; hexane / 1 h / -78 °C

1.2: 90 percent / diethyl ether; hexane / 1 h / -78 °C

2.1: pyridine; SOBr₂ / toluene / 0.17 h / 20 °C

With pyridine; sulfurous dibromide; n-butyllithium; In diethyl ether; hexane; toluene;
DOI:10.1021/jm0204542