rac-3-amino-5-(3-amino-phenyl)-1,5-dimethyl-5,6-dihydro-1H-pyrazin-2-one

Base Information

Chemical Name:rac-3-amino-5-(3-amino-phenyl)-1,5-dimethyl-5,6-dihydro-1H-pyrazin-2-one
CAS No.:1350523-49-7
Molecular Formula:C₁₂H₁₆N₄O
Molecular Weight:232.285
Hs Code.:

Synonyms:rac-3-amino-5-(3-amino-phenyl)-1,5-dimethyl-5,6-dihydro-1H-pyrazin-2-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of rac-3-amino-5-(3-amino-phenyl)-1,5-dimethyl-5,6-dihydro-1H-pyrazin-2-one

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Technology Process of rac-3-amino-5-(3-amino-phenyl)-1,5-dimethyl-5,6-dihydro-1H-pyrazin-2-one

There total 13 articles about rac-3-amino-5-(3-amino-phenyl)-1,5-dimethyl-5,6-dihydro-1H-pyrazin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1350523-48-6
rac-3-amino-1,5-dimethyl-5-(3-nitro-phenyl)-5,6-dihydro-1H-pyrazin-2-one

: 1350523-49-7
rac-3-amino-5-(3-amino-phenyl)-1,5-dimethyl-5,6-dihydro-1H-pyrazin-2-one

Guidance literature:: With palladium on activated charcoal; hydrogen; In ethanol; ethyl acetate; at 20 ℃; for 12h;
DOI:10.1016/j.bmcl.2011.10.050

Reference yield:

: 1350523-44-2
rac-[1-methyl-1-(3-nitro-phenyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester

: 1350523-49-7
rac-3-amino-5-(3-amino-phenyl)-1,5-dimethyl-5,6-dihydro-1H-pyrazin-2-one

Guidance literature:: Multi-step reaction with 7 steps

1: acetic acid / tetrahydrofuran; dichloromethane / 1 h / 20 °C

2: sodium triacetoxy borohydride / 2 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 0 °C

4: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

5: dichloromethane / 72 h / 20 °C

6: ammonia; ammonium chloride / ethanol / 18 h / 75 °C

7: palladium on activated charcoal; hydrogen / ethanol; ethyl acetate / 12 h / 20 °C

With sodium triacetoxy borohydride; hydrogenchloride; palladium on activated charcoal; ammonia; hydrogen; ammonium chloride; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; ethyl acetate;
DOI:10.1016/j.bmcl.2011.10.050

Reference yield:

: 1270385-54-0
rac-2-amino-2-(3-nitro-phenyl)-propan-1-ol

: 1350523-49-7
rac-3-amino-5-(3-amino-phenyl)-1,5-dimethyl-5,6-dihydro-1H-pyrazin-2-one

Guidance literature:: Multi-step reaction with 9 steps

1: sodium hydrogencarbonate / tetrahydrofuran / 0 - 20 °C

2: Dess-Martin periodane / dichloromethane / 1 h / 0 - 20 °C

3: acetic acid / tetrahydrofuran; dichloromethane / 1 h / 20 °C

4: sodium triacetoxy borohydride / 2 h / 20 °C

5: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 0 °C

6: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

7: dichloromethane / 72 h / 20 °C

8: ammonia; ammonium chloride / ethanol / 18 h / 75 °C

9: palladium on activated charcoal; hydrogen / ethanol; ethyl acetate / 12 h / 20 °C

With sodium triacetoxy borohydride; hydrogenchloride; palladium on activated charcoal; ammonia; hydrogen; sodium hydrogencarbonate; ammonium chloride; Dess-Martin periodane; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; ethyl acetate;
DOI:10.1016/j.bmcl.2011.10.050