rac-3-amino-1,5-dimethyl-5-(3-nitro-phenyl)-5,6-dihydro-1H-pyrazin-2-one

Base Information

Chemical Name:rac-3-amino-1,5-dimethyl-5-(3-nitro-phenyl)-5,6-dihydro-1H-pyrazin-2-one
CAS No.:1350523-48-6
Molecular Formula:C₁₂H₁₄N₄O₃
Molecular Weight:262.268
Hs Code.:

Synonyms:rac-3-amino-1,5-dimethyl-5-(3-nitro-phenyl)-5,6-dihydro-1H-pyrazin-2-one

Suppliers and Price of rac-3-amino-1,5-dimethyl-5-(3-nitro-phenyl)-5,6-dihydro-1H-pyrazin-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of rac-3-amino-1,5-dimethyl-5-(3-nitro-phenyl)-5,6-dihydro-1H-pyrazin-2-one

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of rac-3-amino-1,5-dimethyl-5-(3-nitro-phenyl)-5,6-dihydro-1H-pyrazin-2-one

There total 10 articles about rac-3-amino-1,5-dimethyl-5-(3-nitro-phenyl)-5,6-dihydro-1H-pyrazin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 1350523-47-5
rac-3-methoxy-1,5-dimethyl-5-(3-nitro-phenyl)-5,6-dihydro-1H-pyrazin-2-one

: 1350523-48-6
rac-3-amino-1,5-dimethyl-5-(3-nitro-phenyl)-5,6-dihydro-1H-pyrazin-2-one

Guidance literature:: With ammonia; ammonium chloride; In ethanol; at 75 ℃; for 18h;
DOI:10.1016/j.bmcl.2011.10.050

Reference yield:

: 1270385-54-0
rac-2-amino-2-(3-nitro-phenyl)-propan-1-ol

: 1350523-48-6
rac-3-amino-1,5-dimethyl-5-(3-nitro-phenyl)-5,6-dihydro-1H-pyrazin-2-one

Guidance literature:: Multi-step reaction with 8 steps

1: sodium hydrogencarbonate / tetrahydrofuran / 0 - 20 °C

2: Dess-Martin periodane / dichloromethane / 1 h / 0 - 20 °C

3: acetic acid / tetrahydrofuran; dichloromethane / 1 h / 20 °C

4: sodium triacetoxy borohydride / 2 h / 20 °C

5: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 0 °C

6: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

7: dichloromethane / 72 h / 20 °C

8: ammonia; ammonium chloride / ethanol / 18 h / 75 °C

With sodium triacetoxy borohydride; hydrogenchloride; ammonia; sodium hydrogencarbonate; ammonium chloride; Dess-Martin periodane; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2011.10.050

Reference yield:

: 1350523-45-3
rac-[1-methyl-2-methylamino-1-(3-nitro-phenyl)-ethyl]-carbamic acid tert-butyl ester

: 1350523-48-6
rac-3-amino-1,5-dimethyl-5-(3-nitro-phenyl)-5,6-dihydro-1H-pyrazin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 0 °C

2: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

3: dichloromethane / 72 h / 20 °C

4: ammonia; ammonium chloride / ethanol / 18 h / 75 °C

With hydrogenchloride; ammonia; ammonium chloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2011.10.050