5-(3-(9H-purin-6-yl)pyridin-2-yloxy)-N-(4-chlorophenyl)-6-methylisoquinolin-1-amine

Base Information

Chemical Name:5-(3-(9H-purin-6-yl)pyridin-2-yloxy)-N-(4-chlorophenyl)-6-methylisoquinolin-1-amine
CAS No.:1093100-24-3
Molecular Formula:C₂₆H₁₈ClN₇O
Molecular Weight:479.928
Hs Code.:

Synonyms:5-(3-(9H-purin-6-yl)pyridin-2-yloxy)-N-(4-chlorophenyl)-6-methylisoquinolin-1-amine

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Chemical Property of 5-(3-(9H-purin-6-yl)pyridin-2-yloxy)-N-(4-chlorophenyl)-6-methylisoquinolin-1-amine

Chemical Property:

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Technology Process of 5-(3-(9H-purin-6-yl)pyridin-2-yloxy)-N-(4-chlorophenyl)-6-methylisoquinolin-1-amine

There total 14 articles about 5-(3-(9H-purin-6-yl)pyridin-2-yloxy)-N-(4-chlorophenyl)-6-methylisoquinolin-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1093101-60-0
5-(3-(9-(4-methoxybenzyl)-9H-purin-6-yl)pyridin-2-yloxy)-N-(4-chlorophenyl)-6-methylisoquinolin-1-amine

: 1093100-24-3
5-(3-(9H-purin-6-yl)pyridin-2-yloxy)-N-(4-chlorophenyl)-6-methylisoquinolin-1-amine

Guidance literature:: With trifluoroacetic acid; at 65 ℃; for 3.5h;

Reference yield:

: 943606-84-6
1-chloro-6-methyl-5-nitroisoquinoline

: 1093100-24-3
5-(3-(9H-purin-6-yl)pyridin-2-yloxy)-N-(4-chlorophenyl)-6-methylisoquinolin-1-amine

Guidance literature:: Multi-step reaction with 7 steps

1: hydrogenchloride / tetrahydrofuran; water / 14 h / Heating / reflux

2: hydrogen / palladium 10% on activated carbon / acetic acid / 100 h / 20 °C / 760.05 Torr

3: sulfuric acid; sodium nitrite / water / 17 h / 0 - 70 °C

4: caesium carbonate / 1-methyl-pyrrolidin-2-one / 1 h / 130 °C / microwave

5: trichlorophosphate / 1 h / 100 °C

6: lithium hexamethyldisilazane / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; DavePhos / tetrahydrofuran; 1,4-dioxane / 0.75 h / 50 °C

7: trifluoroacetic acid / 3.5 h / 65 °C

With hydrogenchloride; sulfuric acid; hydrogen; caesium carbonate; trifluoroacetic acid; lithium hexamethyldisilazane; sodium nitrite; trichlorophosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; DavePhos; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; water; acetic acid;

Reference yield:

: 42398-73-2,34528-67-1
6-methylisoquinoline

: 1093100-24-3
5-(3-(9H-purin-6-yl)pyridin-2-yloxy)-N-(4-chlorophenyl)-6-methylisoquinolin-1-amine

Guidance literature:: Multi-step reaction with 10 steps

1: sulfuric acid; potassium nitrate / 1.5 h / 0 °C

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 0 °C

3: trichlorophosphate / 1,2-dichloro-ethane / 3 h / 70 °C

4: hydrogenchloride / tetrahydrofuran; water / 14 h / Heating / reflux

5: hydrogen / palladium 10% on activated carbon / acetic acid / 100 h / 20 °C / 760.05 Torr

6: sulfuric acid; sodium nitrite / water / 17 h / 0 - 70 °C

7: caesium carbonate / 1-methyl-pyrrolidin-2-one / 1 h / 130 °C / microwave

8: trichlorophosphate / 1 h / 100 °C

9: lithium hexamethyldisilazane / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; DavePhos / tetrahydrofuran; 1,4-dioxane / 0.75 h / 50 °C

10: trifluoroacetic acid / 3.5 h / 65 °C

With hydrogenchloride; sulfuric acid; hydrogen; caesium carbonate; potassium nitrate; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; lithium hexamethyldisilazane; sodium nitrite; trichlorophosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; DavePhos; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; dichloromethane; water; acetic acid; 1,2-dichloro-ethane;