943606-84-6

Basic information

• Product Name: 1-chloro-6-Methyl-5-nitroisoquinoline
• Synonyms: 1-chloro-6-Methyl-5-nitroisoquinoline
• CAS NO: 943606-84-6
• Molecular Formula: C₁₀H₇ClN₂O₂
• Molecular Weight: 222.62778
• Mol File: 943606-84-6.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 377.6±37.0 °C(Predicted)
• Appearance: /
• Density: 1.419±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 0.67±0.50(Predicted)
• CAS DataBase Reference: 1-chloro-6-Methyl-5-nitroisoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 1-chloro-6-Methyl-5-nitroisoquinoline(943606-84-6)
• EPA Substance Registry System: 1-chloro-6-Methyl-5-nitroisoquinoline(943606-84-6)

Safety Data

• Hazardous Substances Data: 943606-84-6(Hazardous Substances Data)

Usage

General Description

The chemical compound 1-chloro-6-methyl-5-nitroisoquinoline is an organic substance that is part of the isoquinoline family, which is often used in pharmaceuticals and various chemical researches due to their biological activity. The compound has a specific molecular formula of C11H8ClN3O2. It contains atoms of carbon, hydrogen, chlorine, nitrogen, and oxygen, which are bonded in a certain sequence to form a stable structure. The presence of a nitro and a chlorine group on the isoquinoline ring indicates that the compound might exhibit unique chemical and physical properties, although it is not commonly used and its applications are not well documented. Further research and experiment are necessary to fully understand its potential uses.

Synthetic route

6-methyl-5-nitroisoquinoline 2-oxide (943606-83-5) → 1-chloro-6-methyl-5-nitroisoquinoline (943606-84-6)

Conditions	Yield
With trichlorophosphate In chloroform at 70℃; for 3h;	96%
With trichlorophosphate In 1,2-dichloro-ethane at 70℃; for 3h;	86%
With trichlorophosphate In 1,2-dichloro-ethane Reflux;	55%
With trichlorophosphate In 1,2-dichloro-ethane Reflux;	55%
With trichlorophosphate In 1,2-dichloro-ethane at 70℃;	0.88 g

6-methyl-5-nitroisoquinoline (188121-31-5) → 1-chloro-6-methyl-5-nitroisoquinoline (943606-84-6)

Conditions	Yield
With trichlorophosphate In 1,2-dichloro-ethane Reflux;	55%
With trichlorophosphate In 1,2-dichloro-ethane for 7h; Reflux;	55%
Multi-step reaction with 2 steps 1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 °C 2: trichlorophosphate / 1,2-dichloro-ethane / Reflux View Scheme
Multi-step reaction with 2 steps 1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 °C 2: trichlorophosphate / 1,2-dichloro-ethane / Reflux View Scheme
Multi-step reaction with 2 steps 1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 0 °C 2: trichlorophosphate / 1,2-dichloro-ethane / 3 h / 70 °C View Scheme

6-methylisoquinoline N-oxide (70810-28-5) → 1-chloro-6-methyl-5-nitroisoquinoline (943606-84-6)

Conditions	Yield
With potassium nitrate; trichlorophosphate In chloroform; sulfuric acid

6-methylisoquinoline (42398-73-2) → 1-chloro-6-methyl-5-nitroisoquinoline (943606-84-6)

Conditions	Yield
Multi-step reaction with 3 steps 1: sulfuric acid; potassium nitrate / 0 °C 2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 °C 3: trichlorophosphate / 1,2-dichloro-ethane / Reflux View Scheme
Multi-step reaction with 2 steps 1: potassium nitrate; sulfuric acid / 0 °C 2: trichlorophosphate / 1,2-dichloro-ethane / Reflux View Scheme
Multi-step reaction with 2 steps 1: sulfuric acid; potassium nitrate / 3 h / 0 °C 2: trichlorophosphate / 1,2-dichloro-ethane / 7 h / Reflux View Scheme
Multi-step reaction with 3 steps 1: sulfuric acid; potassium nitrate / 0 °C 2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 °C 3: trichlorophosphate / 1,2-dichloro-ethane / Reflux View Scheme
Multi-step reaction with 3 steps 1: sulfuric acid; potassium nitrate / 1.5 h / 0 °C 2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 0 °C 3: trichlorophosphate / 1,2-dichloro-ethane / 3 h / 70 °C View Scheme

4-methyl-benzaldehyde (104-87-0) → 1-chloro-6-methyl-5-nitroisoquinoline (943606-84-6)

Conditions	Yield
Multi-step reaction with 5 steps 1.1: chloroform / 90 °C 2.1: chloroformic acid ethyl ester; triethyl phosphite / chloroform / 24 h / 0 - 20 °C 2.2: 0 °C / Reflux 3.1: sulfuric acid; potassium nitrate / 0 °C 4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 °C 5.1: trichlorophosphate / 1,2-dichloro-ethane / Reflux View Scheme
Multi-step reaction with 3 steps 1.1: chloroform / 90 °C 1.2: 24 h / 0 - 20 °C 1.3: 0 - 20 °C / Reflux 2.1: potassium nitrate; sulfuric acid / 0 °C 3.1: trichlorophosphate / 1,2-dichloro-ethane / Reflux View Scheme
Multi-step reaction with 3 steps 1.1: chloroform / 90 °C 1.2: 24 h / 0 - 20 °C 1.3: 12 h / 0 °C / Reflux 2.1: sulfuric acid; potassium nitrate / 3 h / 0 °C 3.1: trichlorophosphate / 1,2-dichloro-ethane / 7 h / Reflux View Scheme
Multi-step reaction with 4 steps 1.1: chloroform / 90 °C 1.2: 24 h / 0 - 20 °C 1.3: 0 °C / Reflux 2.1: sulfuric acid; potassium nitrate / 0 °C 3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 °C 4.1: trichlorophosphate / 1,2-dichloro-ethane / Reflux View Scheme
Multi-step reaction with 4 steps 1.1: chloroform / 22 - 65 °C 1.2: 23 h / -3 - 20 °C 1.3: 10.5 h / 52 °C 2.1: sulfuric acid; potassium nitrate / 1.5 h / 0 °C 3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 0 °C 4.1: trichlorophosphate / 1,2-dichloro-ethane / 3 h / 70 °C View Scheme

(2,2-Dimethoxy-ethyl)-[1-p-tolyl-meth-(Z)-ylidene]-amine (54879-70-8) → 1-chloro-6-methyl-5-nitroisoquinoline (943606-84-6)

Conditions	Yield
Multi-step reaction with 4 steps 1.1: chloroformic acid ethyl ester; triethyl phosphite / chloroform / 24 h / 0 - 20 °C 1.2: 0 °C / Reflux 2.1: sulfuric acid; potassium nitrate / 0 °C 3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 °C 4.1: trichlorophosphate / 1,2-dichloro-ethane / Reflux View Scheme

1-chloro-6-methyl-5-nitroisoquinoline (943606-84-6) + m-aminobenzenesulfonamide (98-18-0) → C16H14N4O4S

Conditions	Yield
With trifluoroacetic acid In isopropyl alcohol at 20 - 90℃; for 18h; Inert atmosphere;	99.4%

1-chloro-6-methyl-5-nitroisoquinoline (943606-84-6) + 3-(methylsulfonamido)aniline (37045-73-1) → N-(3-((6-methyl-5-nitroisoquinolin-1-yl)amino)phenyl)methanesulfonamide (1446113-45-6)

Conditions	Yield
In isopropyl alcohol at 120℃; for 1.5h; Sealed tube;	99%
In isopropyl alcohol at 120℃; for 1.5h; Sealed tube;	99%

1-chloro-6-methyl-5-nitroisoquinoline (943606-84-6) + 3,5-Dimethoxyaniline (10272-07-8) → C18H17N3O4

Conditions	Yield
With trifluoroacetic acid In isopropyl alcohol at 20 - 90℃; for 16h; Inert atmosphere;	98.4%

1-chloro-6-methyl-5-nitroisoquinoline (943606-84-6) + 3-acetylenephenylamine (54060-30-9) → C18H13N3O2

Conditions	Yield
With trifluoroacetic acid In isopropyl alcohol at 20 - 90℃; for 16h; Inert atmosphere;	95.4%

1-chloro-6-methyl-5-nitroisoquinoline (943606-84-6) + 4-chloro-aniline (106-47-8) → N-(4-chlorophenyl)-6-methyl-5-nitroisoquinolin-1-amine (1191460-78-2)

Conditions	Yield
In isopropyl alcohol at 90℃; Sealed tube;	95%
In isopropyl alcohol at 90℃; Sealed tube;	95%

1-chloro-6-methyl-5-nitroisoquinoline (943606-84-6) + 3-trifluoromethylaniline (98-16-8) → 6-methyl-5-nitro-N-(3-(trifluoromethyl)phenyl)isoquinoline-1-amine (943606-86-8)

Conditions	Yield
In isopropyl alcohol at 90℃; for 12h;	94%
In isopropyl alcohol at 90℃; Sealed tube;	94%
In isopropyl alcohol at 180℃; for 0.416667h; Microwave irradiation;	79%
In isopropyl alcohol at 180℃; for 0.416667h; Microwave irradiation;	79%
In isopropyl alcohol at 180℃; for 0.416667h; microwave;	79%

1-chloro-6-methyl-5-nitroisoquinoline (943606-84-6) + 4-chloro-3-trifluoromethyl-aniline (320-51-4) → C17H11ClF3N3O2

Conditions	Yield
With trifluoroacetic acid In isopropyl alcohol at 20 - 90℃; for 18h; Inert atmosphere;	93.3%

1-chloro-6-methyl-5-nitroisoquinoline (943606-84-6) + m-trifluoromethoxyaniline (1535-73-5) → C17H12F3N3O3

Conditions	Yield
With trifluoroacetic acid In isopropyl alcohol at 20 - 90℃; for 18h; Inert atmosphere;	91.9%

1-chloro-6-methyl-5-nitroisoquinoline (943606-84-6) → 5-amino-1-chloro-6-methylisoquinoline (1093101-44-0)

Conditions	Yield
With hydrogen In tetrahydrofuran at 20℃; under 2250.23 Torr; for 18h; chemoselective reaction;	90.1%
With hydrogenchloride; iron In ethanol; water for 5h; Reflux;	83%
With tin(ll) chloride In ethanol; dichloromethane at 70℃; for 16h;	40%

1-chloro-6-methyl-5-nitroisoquinoline (943606-84-6) + 4-Aminobenzonitrile (873-74-5) → 4-(6-methyl-5-nitroisoquinolin-1-ylamino)benzonitrile (1093101-45-1)

Conditions	Yield
Stage #1: 1-chloro-6-methyl-5-nitroisoquinoline; 4-Aminobenzonitrile In isopropyl alcohol at 22℃; Stage #2: With trifluoroacetic acid In isopropyl alcohol at 80℃; for 17h;	88%

1-chloro-6-methyl-5-nitroisoquinoline (943606-84-6) → 6-methyl-5-nitroisoquinolin-1(2H)-one (943606-85-7)

Conditions	Yield
With hydrogenchloride; water In tetrahydrofuran Heating / reflux;	87%
With hydrogenchloride; water In tetrahydrofuran for 14h; Reflux;	87%
With hydrogenchloride In tetrahydrofuran; water for 14h; Heating / reflux;	87%

1-chloro-6-methyl-5-nitroisoquinoline (943606-84-6) + 4-chloro-aniline (106-47-8) → N-(4-chlorophenyl)-6-methyl-5-nitroisoquinolin-1-amine hydrochloride (1191385-24-6)

Conditions	Yield
In isopropyl alcohol at 170℃; for 0.266667h; Microwave irradiation;	84%

1-chloro-6-methyl-5-nitroisoquinoline (943606-84-6) → 1-methoxy-6-methyl-5-nitroisoquinoline (260049-39-6)

Conditions	Yield
With sodium methylate In methanol	74%

1-chloro-6-methyl-5-nitroisoquinoline (943606-84-6) + 2,4-difluorophenylamine (367-25-9) → C16H11F2N3O2

Conditions	Yield
With trifluoroacetic acid In isopropyl alcohol at 20 - 90℃; for 16h; Inert atmosphere;	73.7%

1-chloro-6-methyl-5-nitroisoquinoline (943606-84-6) + tert-butyl 4-(5-amino-2-chlorobenzyl)piperazine-1-carboxylate (769961-14-0) → tert-butyl 4-(2-chloro-5-((6-methyl-5-nitroisoquinolin-1-yl)amino)benzyl)piperazine-1-carboxylate (1446113-47-8)

Conditions	Yield
With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In 1,4-dioxane at 130℃; for 3h; Sealed tube;	54%
With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In 1,4-dioxane at 130℃; for 3h; Sealed tube;	54%

4-chloro-3-((dimethylamino)methyl)aniline + 1-chloro-6-methyl-5-nitroisoquinoline (943606-84-6) → N-(4-chloro-3-((dimethylamino)methyl)phenyl)-6-methyl-5-nitroisoquinolin-1-amine (1446113-42-3)

Conditions	Yield
With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In 1,4-dioxane at 130℃; for 3h;	53%
With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In 1,4-dioxane at 130℃; for 3h; Sealed tube;	53%

1-chloro-6-methyl-5-nitroisoquinoline (943606-84-6) + 2-amino-4-(trifluoromethyl)pyridine (106447-97-6) → 6-methyl-5-nitro-N-(4-(trifluoromethyl)pyridin-2-yl)isoquinolin-1-amine (1446113-36-5)

Conditions	Yield
With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In 1,4-dioxane at 110℃; Sealed tube;	42%
With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In 1,4-dioxane at 110℃;	42%

1-chloro-6-methyl-5-nitroisoquinoline (943606-84-6) + 5-tert-butyl-2-methyl-2H-pyrazol-3-ylamine (118430-73-2) → C18H21N5O2

Conditions	Yield
With tris-(dibenzylideneacetone)dipalladium(0); lithium hexamethyldisilazane; DavePhos In 1,4-dioxane at 150℃; for 0.5h; Microwave irradiation; Sealed tube;	32.8%

1-chloro-6-methyl-5-nitroisoquinoline (943606-84-6) + (R)-1-(4-chlorophenyl)ethylamine (27298-99-3) → (R)-N-(1-(4-chlorophenyl)ethyl)-6-methyl-5-nitroisoquinolin-1-amine (1093101-68-8)

Conditions	Yield
With trifluoroacetic acid In isopropyl alcohol at 140℃; for 1h; microwave;

1-chloro-6-methyl-5-nitroisoquinoline (943606-84-6) → 5-amino-1-chloro-6-methylisoquinoline (1093101-44-0) + 5-amino-6-methylisoquinoline (188120-79-8)

Conditions	Yield
With 5%-palladium/activated carbon; hydrogen In tetrahydrofuran at 37℃; under 2250.23 - 3000.3 Torr; for 15h;	A 84.4 %Chromat. B 15.6 %Chromat.

1-chloro-6-methyl-5-nitroisoquinoline (943606-84-6) → N1-(4-chloro-3-((dimethylamino)methyl)phenyl)-6-methylisoquinoline-1,5-diamine (1446113-43-4)

Conditions	Yield
Multi-step reaction with 2 steps 1: 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate / 1,4-dioxane / 3 h / 130 °C 2: iron; hydrogenchloride / water; ethanol / 1 h / Reflux View Scheme
Multi-step reaction with 2 steps 1: tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; caesium carbonate / 1,4-dioxane / 3 h / 130 °C / Sealed tube 2: hydrogenchloride; iron / water; ethanol / 1 h / Reflux View Scheme

1-chloro-6-methyl-5-nitroisoquinoline (943606-84-6) → 4-amino-N-(1-((4-chloro-3-((dimethylamino)methyl)phenyl)amino)-6-methylisoquinolin-5-yl)thieno[3,2-d]pyrimidine-7-carboxamide (1446112-11-3)

Conditions	Yield
Multi-step reaction with 3 steps 1: 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate / 1,4-dioxane / 3 h / 130 °C 2: iron; hydrogenchloride / water; ethanol / 1 h / Reflux 3: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h View Scheme
Multi-step reaction with 3 steps 1: tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; caesium carbonate / 1,4-dioxane / 3 h / 130 °C / Sealed tube 2: hydrogenchloride; iron / water; ethanol / 1 h / Reflux 3: N-[(dimethylamino)-1H-1,2,3-triazolo-[4,5-b]pyridin-1-ylmethylene]-N-methylmethanaminium hexafluorophosphate N-oxide; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide View Scheme

1-chloro-6-methyl-5-nitroisoquinoline (943606-84-6) → N-(3-((5-amino-6-methylisoquinolin-1-yl)amino)phenyl)methanesulfonamide (1446113-46-7)

Conditions	Yield
Multi-step reaction with 2 steps 1: isopropyl alcohol / 1.5 h / 120 °C / Sealed tube 2: iron; hydrogenchloride / water; ethanol / 3 h / Reflux View Scheme
Multi-step reaction with 2 steps 1: isopropyl alcohol / 1.5 h / 120 °C / Sealed tube 2: hydrogenchloride; iron / water; ethanol / 3 h / Reflux View Scheme

1-chloro-6-methyl-5-nitroisoquinoline (943606-84-6) → 4-amino-N-(6-methyl-1-((3-(methylsulfonamido)phenyl)amino)isoquinolin-5-yl)thieno[3,2-d]pyrimidine-7-carboxamide (1446112-26-0)

Conditions	Yield
Multi-step reaction with 3 steps 1: isopropyl alcohol / 1.5 h / 120 °C / Sealed tube 2: iron; hydrogenchloride / water; ethanol / 3 h / Reflux 3: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h View Scheme
Multi-step reaction with 3 steps 1: isopropyl alcohol / 1.5 h / 120 °C / Sealed tube 2: hydrogenchloride; iron / water; ethanol / 3 h / Reflux 3: N-[(dimethylamino)-1H-1,2,3-triazolo-[4,5-b]pyridin-1-ylmethylene]-N-methylmethanaminium hexafluorophosphate N-oxide; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h View Scheme

1-chloro-6-methyl-5-nitroisoquinoline (943606-84-6) → tert-butyl 4-(5-((5-amino-6-methylisoquinolin-1-yl)amino)-2-chlorobenzyl)piperazine-1-carboxylate (1446113-48-9)

Conditions	Yield
Multi-step reaction with 2 steps 1: 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate / 1,4-dioxane / 3 h / 130 °C / Sealed tube 2: iron; hydrogenchloride / water; ethanol / 3 h / Reflux View Scheme
Multi-step reaction with 2 steps 1: tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; caesium carbonate / 1,4-dioxane / 3 h / 130 °C / Sealed tube 2: hydrogenchloride; iron / water; ethanol / 3 h / Reflux View Scheme

Upstream product

• 607-32-9 5-nitroisoquinoline 
• 54879-70-8 (2,2-Dimethoxy-ethyl)-[1-p-tolyl-meth-(Z)-ylidene]-amine 
• 188121-31-5 6-methyl-5-nitroisoquinoline 
• 104-87-0 4-methyl-benzaldehyde 
• 42398-73-2 6-methylisoquinoline 
• 943606-83-5 6-methyl-5-nitroisoquinoline N-oxide 
• 70810-28-5 6-methylisoquinoline N-oxide 

Downstream Products

• 943606-85-7 6-methyl-5-nitroisoquinolin-1(2H)-one 
• 1446113-45-6 N-(3-((6-methyl-5-nitroisoquinolin-1-yl)amino)phenyl)methanesulfonamide 
• 1446113-47-8 tert-butyl 4-(2-chloro-5-((6-methyl-5-nitroisoquinolin-1-yl)amino)benzyl)piperazine-1-carboxylate 
• 1446113-43-4 N¹-(4-chloro-3-((dimethylamino)methyl)phenyl)-6-methylisoquinoline-1,5-diamine 
• 1446112-11-3 4-amino-N-(1-((4-chloro-3-((dimethylamino)methyl)phenyl)amino)-6-methylisoquinolin-5-yl)thieno[3,2-d]pyrimidine-7-carboxamide 
• 1446113-46-7 N-(3-((6-methyl-5-aminoisoquinolin-1-yl)amino)phenyl)methanesulfonamide 
• 1446112-26-0 4-amino-N-(6-methyl-1-((3-(methylsulfonamido)phenyl)amino)isoquinolin-5-yl)thieno[3,2-d]pyrimidine-7-carboxamide 
• 1446113-48-9 tert-butyl 4-(5-((5-amino-6-methylisoquinolin-1-yl)amino)-2-chlorobenzyl)piperazine-1-carboxylate 
• 1446112-28-2 tert-butyl 4-(5-((5-(4-aminothieno[3,2-d]pyrimidine-7-carboxamido)-6-methylisoquinolin-1-yl)amino)-2-chlorobenzyl)piperazine-1-carboxylate 
• 1446112-30-6 4-amino-N-(1-((4-chloro-3-(piperazin-1-ylmethyl)phenyl)amino)-6-methylisoquinolin-5-yl)thieno[3,2-d]pyrimidine-7-carboxamide hydrochloride 
• 1093101-72-4 N¹-(4-chlorophenyl)-6-methylisoquinoline-1,5-diamine 
• 1446111-26-7 4-amino-N-(1-((4-chlorophenyl)amino)-6-methylisoquinolin-5-yl)thieno[3,2-d]pyrimidine-7-carboxamide 
• 1191460-78-2 N-(4-chlorophenyl)-6-methyl-5-nitroisoquinolin-1-amine 
• 1093100-17-4 4-(5-(3-(9-(4-methoxybenzyl)-9H-purin-6-yl)pyridin-2-ylamino)-6-methylisoquinolin-1-ylamino)benzonitrile 

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