((3aR,5R,6R,7S,7aR)-6,7-Bis-benzyloxy-2-methoxy-2-methyl-tetrahydro-[1,3]dioxolo[4,5-b]pyran-5-ylmethoxy)-tert-butyl-dimethyl-silane

Base Information

Chemical Name:((3aR,5R,6R,7S,7aR)-6,7-Bis-benzyloxy-2-methoxy-2-methyl-tetrahydro-[1,3]dioxolo[4,5-b]pyran-5-ylmethoxy)-tert-butyl-dimethyl-silane
CAS No.:250734-70-4
Molecular Formula:C₂₉H₄₂O₇Si
Molecular Weight:530.734
Hs Code.:

Synonyms:((3aR,5R,6R,7S,7aR)-6,7-Bis-benzyloxy-2-methoxy-2-methyl-tetrahydro-[1,3]dioxolo[4,5-b]pyran-5-ylmethoxy)-tert-butyl-dimethyl-silane

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Chemical Property of ((3aR,5R,6R,7S,7aR)-6,7-Bis-benzyloxy-2-methoxy-2-methyl-tetrahydro-[1,3]dioxolo[4,5-b]pyran-5-ylmethoxy)-tert-butyl-dimethyl-silane

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Technology Process of ((3aR,5R,6R,7S,7aR)-6,7-Bis-benzyloxy-2-methoxy-2-methyl-tetrahydro-[1,3]dioxolo[4,5-b]pyran-5-ylmethoxy)-tert-butyl-dimethyl-silane

There total 3 articles about ((3aR,5R,6R,7S,7aR)-6,7-Bis-benzyloxy-2-methoxy-2-methyl-tetrahydro-[1,3]dioxolo[4,5-b]pyran-5-ylmethoxy)-tert-butyl-dimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 100-39-0
benzyl bromide

: 250734-68-0
(3aR,5R,6S,7S,7aR)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-2-methoxy-2-methyl-tetrahydro-[1,3]dioxolo[4,5-b]pyran-6,7-diol

: 250734-70-4
((3aR,5R,6R,7S,7aR)-6,7-Bis-benzyloxy-2-methoxy-2-methyl-tetrahydro-[1,3]dioxolo[4,5-b]pyran-5-ylmethoxy)-tert-butyl-dimethyl-silane

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 1h;
DOI:10.1002/(sici)1099-0690(199910)1999:10<2523::aid-ejoc2523>3.0.co;2-q

Reference yield:

: 3254-16-8,4435-05-6,19189-54-9,29748-21-8,50801-29-1,64727-26-0,64727-27-1,65338-02-5,67672-68-8,78418-55-0,80877-03-8,103002-27-3,103002-29-5,132562-62-0
3,4,6-tri-O-acetyl-[1,2-O-(1-methoxyethylidene)]-α-D-glucopyranose

: 250734-70-4
((3aR,5R,6R,7S,7aR)-6,7-Bis-benzyloxy-2-methoxy-2-methyl-tetrahydro-[1,3]dioxolo[4,5-b]pyran-5-ylmethoxy)-tert-butyl-dimethyl-silane

Guidance literature:: Multi-step reaction with 3 steps

1.1: K₂CO₃ / methanol / 0.5 h / 22 °C

2.1: (Bu₃Sn)2O / toluene / 3 h / Heating

2.2: Bu₄NBr / CH₂Cl₂ / 0.5 h / 22 °C

3.1: 96 percent / NaH / dimethylformamide / 1 h / 0 °C

With sodium hydride; potassium carbonate; bis(tri-n-butyltin)oxide; In methanol; N,N-dimethyl-formamide; toluene; 1.1: Methanolyis / 2.1: Etherification / 2.2: Silylation / 3.1: Benzylation;
DOI:10.1002/(sici)1099-0690(199910)1999:10<2523::aid-ejoc2523>3.0.co;2-q

Reference yield:

: 29073-91-4,138196-19-7,55865-04-8
(3aR,5R,6S,7S,7aR)-5-Hydroxymethyl-2-methoxy-2-methyl-tetrahydro-[1,3]dioxolo[4,5-b]pyran-6,7-diol

: 250734-70-4
((3aR,5R,6R,7S,7aR)-6,7-Bis-benzyloxy-2-methoxy-2-methyl-tetrahydro-[1,3]dioxolo[4,5-b]pyran-5-ylmethoxy)-tert-butyl-dimethyl-silane

Guidance literature:: Multi-step reaction with 2 steps

1.1: (Bu₃Sn)2O / toluene / 3 h / Heating

1.2: Bu₄NBr / CH₂Cl₂ / 0.5 h / 22 °C

2.1: 96 percent / NaH / dimethylformamide / 1 h / 0 °C

With sodium hydride; bis(tri-n-butyltin)oxide; In N,N-dimethyl-formamide; toluene; 1.1: Etherification / 1.2: Silylation / 2.1: Benzylation;
DOI:10.1002/(sici)1099-0690(199910)1999:10<2523::aid-ejoc2523>3.0.co;2-q