2-(4-hydroxyphenyl)-N-[5-(4-hydroxyphenyl)-3-phenethylpyrazin-2-yl]acetamide

Base Information

Chemical Name:2-(4-hydroxyphenyl)-N-[5-(4-hydroxyphenyl)-3-phenethylpyrazin-2-yl]acetamide
CAS No.:1338220-57-7
Molecular Formula:C₂₆H₂₃N₃O₃
Molecular Weight:425.487
Hs Code.:

Synonyms:2-(4-hydroxyphenyl)-N-[5-(4-hydroxyphenyl)-3-phenethylpyrazin-2-yl]acetamide

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Chemical Property of 2-(4-hydroxyphenyl)-N-[5-(4-hydroxyphenyl)-3-phenethylpyrazin-2-yl]acetamide

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Technology Process of 2-(4-hydroxyphenyl)-N-[5-(4-hydroxyphenyl)-3-phenethylpyrazin-2-yl]acetamide

There total 20 articles about 2-(4-hydroxyphenyl)-N-[5-(4-hydroxyphenyl)-3-phenethylpyrazin-2-yl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.3%

: 1338221-26-3
2-[4-(tert-butyldimethylsilyloxy)phenyl]-N-[5-{4-(tert-butyldimethylsilyloxy)phenyl}-3-phenethylpyrazin-2-yl]acetamide

: 1338220-57-7
2-(4-hydroxyphenyl)-N-[5-(4-hydroxyphenyl)-3-phenethylpyrazin-2-yl]acetamide

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 - 20 ℃; for 0.5h;

Reference yield:

: 2-[4-(tert-butyldimethylsilyloxy)phenyl]acetyl chloride

: 1338221-21-8
5-[4-(tert-butyldimethylsilyloxy)phenyl]-3-(phenylethynyl)pyrazin-2-amine

: 1338220-53-3
2-(4-hydroxyphenyl)-N-[5-(4-hydroxyphenyl)-3-(phenylethynyl)pyrazin-2-yl]acetamide

: 1338220-57-7
2-(4-hydroxyphenyl)-N-[5-(4-hydroxyphenyl)-3-phenethylpyrazin-2-yl]acetamide

: C₂₆H₂₁N₃O₃

Guidance literature:: 5-[4-(tert-butyldimethylsilyloxy)phenyl]-3-(phenylethynyl)pyrazin-2-amine; With 10 percent palladium on barium sulphate; hydrogen; In ethyl acetate; at 20 ℃; for 3h; Inert atmosphere;

2-[4-(tert-butyldimethylsilyloxy)phenyl]acetyl chloride; With pyridine; dmap; at 50 ℃; for 20h; Inert atmosphere;

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 - 20 ℃; for 0.5h;

Reference yield:

: 1338221-21-8
5-[4-(tert-butyldimethylsilyloxy)phenyl]-3-(phenylethynyl)pyrazin-2-amine

: 1338220-57-7
2-(4-hydroxyphenyl)-N-[5-(4-hydroxyphenyl)-3-phenethylpyrazin-2-yl]acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: palladium/charcoal / dichloromethane; ethyl acetate

2: dmap / dichloromethane; N,N-dimethyl-formamide; pyridine; water

3: ammonium chloride; tetrabutyl ammonium fluoride / tetrahydrofuran

With dmap; ammonium chloride; tetrabutyl ammonium fluoride; palladium/charcoal; In tetrahydrofuran; pyridine; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;