(R)-methyl 4-(tert-butyldimethylsilyloxy)-2-(tert-butyldiphenylsilyloxy)butanoate

Base Information

Chemical Name:(R)-methyl 4-(tert-butyldimethylsilyloxy)-2-(tert-butyldiphenylsilyloxy)butanoate
CAS No.:1344148-85-1
Molecular Formula:C₂₇H₄₂O₄Si₂
Molecular Weight:486.799
Hs Code.:

Synonyms:(R)-methyl 4-(tert-butyldimethylsilyloxy)-2-(tert-butyldiphenylsilyloxy)butanoate

Suppliers and Price of (R)-methyl 4-(tert-butyldimethylsilyloxy)-2-(tert-butyldiphenylsilyloxy)butanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-methyl 4-(tert-butyldimethylsilyloxy)-2-(tert-butyldiphenylsilyloxy)butanoate

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Technology Process of (R)-methyl 4-(tert-butyldimethylsilyloxy)-2-(tert-butyldiphenylsilyloxy)butanoate

There total 1 articles about (R)-methyl 4-(tert-butyldimethylsilyloxy)-2-(tert-butyldiphenylsilyloxy)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 398517-02-7
(R)-3-[2-(tert-butyldimethylsilyloxy)ethyl]-1,4-dioxaspiro[4.5]decan-2-one

: 1344148-85-1
(R)-methyl 4-(tert-butyldimethylsilyloxy)-2-(tert-butyldiphenylsilyloxy)butanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: methanol / 1 h / 0 °C

1.2: Amberlyst acidic resin / pH 6

2.1: 1H-imidazole; dmap / N,N-dimethyl-formamide / 17 h / 20 °C

With 1H-imidazole; methanol; dmap; In N,N-dimethyl-formamide;
DOI:10.1016/j.tetlet.2011.08.160

Reference yield: 39.0%

: 1344148-85-1
(R)-methyl 4-(tert-butyldimethylsilyloxy)-2-(tert-butyldiphenylsilyloxy)butanoate

: 1344148-87-3
(R)-4-(tert-butyldimethylsilyloxy)-2-(tert-butyldiphenylsilyloxy)butanal

: 1344148-86-2
(R)-4-(tert-butyldimethylsilyloxy)-2-(tert-butyldiphenylsilyloxy)butan-1-ol

Guidance literature:: (R)-methyl 4-(tert-butyldimethylsilyloxy)-2-(tert-butyldiphenylsilyloxy)butanoate; With diisobutylaluminium hydride; In hexane; dichloromethane; at -78 ℃; for 7h;

With water; sodium hydroxide; In hexane; dichloromethane; tert-butyl methyl ether;
DOI:10.1016/j.tetlet.2011.08.160

Reference yield:

: 1344148-85-1
(R)-methyl 4-(tert-butyldimethylsilyloxy)-2-(tert-butyldiphenylsilyloxy)butanoate

: 1344148-93-1
(R)-2-(tert-butyldiphenylsilyloxy)tetradecan-1-ol

Guidance literature:: Multi-step reaction with 7 steps

1.1: diisobutylaluminium hydride / hexane; dichloromethane / 7 h / -78 °C

2.1: pyridine; dmap / 3 h / 0 - 20 °C

3.1: pyridine; pyridine hydrofluoride / tetrahydrofuran / 7 h / 0 - 20 °C

4.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene / dichloromethane / 6 h / 20 °C

5.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / 0 °C

5.2: 0.17 h / 0 °C

6.1: palladium 10% on activated carbon; hydrogen / methanol / 41 h / 20 °C

7.1: diisobutylaluminium hydride / dichloromethane; toluene / 0.5 h / -78 °C

With pyridine; dmap; n-butyllithium; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; pyridine hydrofluoride; [bis(acetoxy)iodo]benzene; palladium 10% on activated carbon; hydrogen; diisobutylaluminium hydride; In tetrahydrofuran; methanol; hexane; dichloromethane; toluene; 5.1: Wittig reaction / 5.2: Wittig reaction;
DOI:10.1016/j.tetlet.2011.08.160