(R)-4-(tert-butyldimethylsilyloxy)-2-(tert-butyldiphenylsilyloxy)butanal

Base Information

Chemical Name:(R)-4-(tert-butyldimethylsilyloxy)-2-(tert-butyldiphenylsilyloxy)butanal
CAS No.:1344148-87-3
Molecular Formula:C₂₆H₄₀O₃Si₂
Molecular Weight:456.773
Hs Code.:

Synonyms:(R)-4-(tert-butyldimethylsilyloxy)-2-(tert-butyldiphenylsilyloxy)butanal

Suppliers and Price of (R)-4-(tert-butyldimethylsilyloxy)-2-(tert-butyldiphenylsilyloxy)butanal

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-4-(tert-butyldimethylsilyloxy)-2-(tert-butyldiphenylsilyloxy)butanal

Chemical Property:

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Technology Process of (R)-4-(tert-butyldimethylsilyloxy)-2-(tert-butyldiphenylsilyloxy)butanal

There total 3 articles about (R)-4-(tert-butyldimethylsilyloxy)-2-(tert-butyldiphenylsilyloxy)butanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 1344148-85-1
(R)-methyl 4-(tert-butyldimethylsilyloxy)-2-(tert-butyldiphenylsilyloxy)butanoate

: 1344148-87-3
(R)-4-(tert-butyldimethylsilyloxy)-2-(tert-butyldiphenylsilyloxy)butanal

: 1344148-86-2
(R)-4-(tert-butyldimethylsilyloxy)-2-(tert-butyldiphenylsilyloxy)butan-1-ol

Guidance literature:: (R)-methyl 4-(tert-butyldimethylsilyloxy)-2-(tert-butyldiphenylsilyloxy)butanoate; With diisobutylaluminium hydride; In hexane; dichloromethane; at -78 ℃; for 7h;

With water; sodium hydroxide; In hexane; dichloromethane; tert-butyl methyl ether;
DOI:10.1016/j.tetlet.2011.08.160

Reference yield:

: 398517-02-7
(R)-3-[2-(tert-butyldimethylsilyloxy)ethyl]-1,4-dioxaspiro[4.5]decan-2-one

: 1344148-87-3
(R)-4-(tert-butyldimethylsilyloxy)-2-(tert-butyldiphenylsilyloxy)butanal

Guidance literature:: Multi-step reaction with 3 steps

1.1: methanol / 1 h / 0 °C

1.2: Amberlyst acidic resin / pH 6

2.1: 1H-imidazole; dmap / N,N-dimethyl-formamide / 17 h / 20 °C

3.1: diisobutylaluminium hydride / hexane; dichloromethane / 7 h / -78 °C

With 1H-imidazole; methanol; dmap; diisobutylaluminium hydride; In hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tetlet.2011.08.160

Reference yield:

: 307532-01-0
(R)-methyl 4-(tert-butyldimethylsilyloxy)-2-hydroxybutanoate

: 1344148-87-3
(R)-4-(tert-butyldimethylsilyloxy)-2-(tert-butyldiphenylsilyloxy)butanal

Guidance literature:: Multi-step reaction with 2 steps

1: 1H-imidazole; dmap / N,N-dimethyl-formamide / 17 h / 20 °C

2: diisobutylaluminium hydride / hexane; dichloromethane / 7 h / -78 °C

With 1H-imidazole; dmap; diisobutylaluminium hydride; In hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tetlet.2011.08.160