Technology Process of phenyl 5-(benzyloxy)-2-bromo-3-methylisonicotinate
There total 7 articles about phenyl 5-(benzyloxy)-2-bromo-3-methylisonicotinate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C20H17NO4;
With
phosphorus(V) oxybromide;
In
toluene;
at 80 ℃;
for 0.5h;
With
potassium carbonate;
In
water; toluene;
at 20 ℃;
for 0.5h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane
2: dmap; triethylamine / dichloromethane / 1 h
3: (bis(tricyclohexyl)phosphine)palladium(II) dichloride; anhydrous dipotassium phosphate / water; toluene / 16 h / 100 °C
4: dihydrogen peroxide / water; acetic acid / 6 h / 80 °C
5: phosphorus(V) oxybromide / toluene / 0.5 h / 80 °C
With
dmap; (bis(tricyclohexyl)phosphine)palladium(II) dichloride; anhydrous dipotassium phosphate; oxalyl dichloride; dihydrogen peroxide; triethylamine; N,N-dimethyl-formamide; phosphorus(V) oxybromide;
In
dichloromethane; water; acetic acid; toluene;
3: Suzuki coupling;
DOI:10.1021/jm1015389
- Guidance literature:
-
Multi-step reaction with 3 steps
1: (bis(tricyclohexyl)phosphine)palladium(II) dichloride; anhydrous dipotassium phosphate / water; toluene / 16 h / 100 °C
2: dihydrogen peroxide / water; acetic acid / 6 h / 80 °C
3: phosphorus(V) oxybromide / toluene / 0.5 h / 80 °C
With
(bis(tricyclohexyl)phosphine)palladium(II) dichloride; anhydrous dipotassium phosphate; dihydrogen peroxide; phosphorus(V) oxybromide;
In
water; acetic acid; toluene;
1: Suzuki coupling;
DOI:10.1021/jm1015389
