benzyl (4R)-N-[N-(N-benzyloxycarbonyl-glycyl)-L-prolyl]-4-aminopentanoate

Base Information

Chemical Name:benzyl (4R)-N-[N-(N-benzyloxycarbonyl-glycyl)-L-prolyl]-4-aminopentanoate
CAS No.:841233-71-4
Molecular Formula:C₂₇H₃₃N₃O₆
Molecular Weight:495.576
Hs Code.:

Synonyms:benzyl (4R)-N-[N-(N-benzyloxycarbonyl-glycyl)-L-prolyl]-4-aminopentanoate

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Chemical Property of benzyl (4R)-N-[N-(N-benzyloxycarbonyl-glycyl)-L-prolyl]-4-aminopentanoate

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Technology Process of benzyl (4R)-N-[N-(N-benzyloxycarbonyl-glycyl)-L-prolyl]-4-aminopentanoate

There total 5 articles about benzyl (4R)-N-[N-(N-benzyloxycarbonyl-glycyl)-L-prolyl]-4-aminopentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: C₁₈H₂₂N₂O₇

: benzyl (4R)-4-aminopentanoate p-toluenesulfonic acid salt

: 841233-71-4
benzyl (4R)-N-[N-(N-benzyloxycarbonyl-glycyl)-L-prolyl]-4-aminopentanoate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃;
DOI:10.1016/j.bmc.2004.10.005

Reference yield:

: 1138-80-3
N-(Benzyloxycarbonyl)glycine

: 841233-71-4
benzyl (4R)-N-[N-(N-benzyloxycarbonyl-glycyl)-L-prolyl]-4-aminopentanoate

Guidance literature:: Multi-step reaction with 4 steps

1: 0.88 g / 1,3-dicyclohexylcarbodiimide; triethylamine / CH₂Cl₂ / 18 h / 20 °C

2: NaOH / H₂O; dioxane / 21 h / 20 °C

3: triethylamine / CH₂Cl₂ / 0.67 h / 0 °C

4: 80 percent / triethylamine / CH₂Cl₂ / 20 °C

With sodium hydroxide; triethylamine; dicyclohexyl-carbodiimide; In 1,4-dioxane; dichloromethane; water;
DOI:10.1016/j.bmc.2004.10.005

Reference yield:

: 66449-90-9
(2S)-N-(N-Benzyloxycarbonylglycyl)proline methyl ester

: 841233-71-4
benzyl (4R)-N-[N-(N-benzyloxycarbonyl-glycyl)-L-prolyl]-4-aminopentanoate

Guidance literature:: Multi-step reaction with 3 steps

1: NaOH / H₂O; dioxane / 21 h / 20 °C

2: triethylamine / CH₂Cl₂ / 0.67 h / 0 °C

3: 80 percent / triethylamine / CH₂Cl₂ / 20 °C

With sodium hydroxide; triethylamine; In 1,4-dioxane; dichloromethane; water;
DOI:10.1016/j.bmc.2004.10.005