(S)-3-benzoyl-1-(1-(bis(4-methoxyphenyl)(phenyl)methoxy)-3-((tert-butyldiphenylsilyl)oxy)propan-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

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Chemical Name:(S)-3-benzoyl-1-(1-(bis(4-methoxyphenyl)(phenyl)methoxy)-3-((tert-butyldiphenylsilyl)oxy)propan-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
CAS No.:1443744-36-2
Molecular Formula:C₅₂H₅₂N₂O₇Si
Molecular Weight:845.08
Hs Code.:

Synonyms:(S)-3-benzoyl-1-(1-(bis(4-methoxyphenyl)(phenyl)methoxy)-3-((tert-butyldiphenylsilyl)oxy)propan-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

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Chemical Property of (S)-3-benzoyl-1-(1-(bis(4-methoxyphenyl)(phenyl)methoxy)-3-((tert-butyldiphenylsilyl)oxy)propan-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

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Technology Process of (S)-3-benzoyl-1-(1-(bis(4-methoxyphenyl)(phenyl)methoxy)-3-((tert-butyldiphenylsilyl)oxy)propan-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

There total 5 articles about (S)-3-benzoyl-1-(1-(bis(4-methoxyphenyl)(phenyl)methoxy)-3-((tert-butyldiphenylsilyl)oxy)propan-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1’-O-([4,4’-dimethoxytriphenyl]methyl)-3’-O-(t-butyldiphenylsilyl)-(S)-propan-2-ol

: 90330-19-1
N³-benzoylthymine

: 1443744-36-2
(S)-3-benzoyl-1-(1-(bis(4-methoxyphenyl)(phenyl)methoxy)-3-((tert-butyldiphenylsilyl)oxy)propan-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In 1,4-dioxane; for 0.5h; Inert atmosphere; Sonication;
DOI:10.1002/anie.201300795

Reference yield: 74.0%

: (R)-1-(bis(4-methoxyphenyl)(phenyl)methoxy)-3-((tert-butyldiphenylsilyl)oxy)propan-2-ol

: 4330-20-5
N-3-benzoylthymine

: 1443744-36-2
(S)-3-benzoyl-1-(1-(bis(4-methoxyphenyl)(phenyl)methoxy)-3-((tert-butyldiphenylsilyl)oxy)propan-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In 1,4-dioxane; at -10 - 20 ℃; for 6h; Inert atmosphere;
DOI:10.3762/bjoc.10.220

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 1443744-36-2
(S)-3-benzoyl-1-(1-(bis(4-methoxyphenyl)(phenyl)methoxy)-3-((tert-butyldiphenylsilyl)oxy)propan-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 4 steps

1: dmap; triethylamine / dichloromethane / 20 °C

2: hydrogenchloride / dichloromethane; water / 0.5 h / 20 °C

3: dmap; pyridine / 48 h / 0 - 20 °C

4: di-isopropyl azodicarboxylate; triphenylphosphine / 1,4-dioxane / 0.5 h / Inert atmosphere; Sonication

With pyridine; hydrogenchloride; dmap; di-isopropyl azodicarboxylate; triethylamine; triphenylphosphine; In 1,4-dioxane; dichloromethane; water;
DOI:10.1002/anie.201300795