17-(cyclopropylmethyl)-6,7-didehydro-4,5H-epoxy-3,6,14-trihydroxy-N-[2-(3-phenyl-1,2,4-oxadiazol-5-yl)propan-2-yl]morphinan-7-carboxamide 4-methylbenzenesulfonic acid tosylate

Base Information

Chemical Name:17-(cyclopropylmethyl)-6,7-didehydro-4,5H-epoxy-3,6,14-trihydroxy-N-[2-(3-phenyl-1,2,4-oxadiazol-5-yl)propan-2-yl]morphinan-7-carboxamide 4-methylbenzenesulfonic acid tosylate
CAS No.:1345728-04-2
Molecular Formula:C₇H₈O₃S*C₃₂H₃₄N₄O₆
Molecular Weight:742.85
Hs Code.:

17-(cyclopropylmethyl)-6,7-didehydro-4,5H-epoxy-3,6,14-trihydroxy-N-[2-(3-phenyl-1,2,4-oxadiazol-5-yl)propan-2-yl]morphinan-7-carboxamide 4-methylbenzenesulfonic acid tosylate

Synonyms:17-(cyclopropylmethyl)-6,7-didehydro-4,5H-epoxy-3,6,14-trihydroxy-N-[2-(3-phenyl-1,2,4-oxadiazol-5-yl)propan-2-yl]morphinan-7-carboxamide 4-methylbenzenesulfonic acid tosylate

Suppliers and Price of 17-(cyclopropylmethyl)-6,7-didehydro-4,5H-epoxy-3,6,14-trihydroxy-N-[2-(3-phenyl-1,2,4-oxadiazol-5-yl)propan-2-yl]morphinan-7-carboxamide 4-methylbenzenesulfonic acid tosylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 17-(cyclopropylmethyl)-6,7-didehydro-4,5H-epoxy-3,6,14-trihydroxy-N-[2-(3-phenyl-1,2,4-oxadiazol-5-yl)propan-2-yl]morphinan-7-carboxamide 4-methylbenzenesulfonic acid tosylate

Chemical Property:

Purity/Quality:: 99% ,99.9%, ^*data from raw suppliers

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Technology Process of 17-(cyclopropylmethyl)-6,7-didehydro-4,5H-epoxy-3,6,14-trihydroxy-N-[2-(3-phenyl-1,2,4-oxadiazol-5-yl)propan-2-yl]morphinan-7-carboxamide 4-methylbenzenesulfonic acid tosylate

There total 9 articles about 17-(cyclopropylmethyl)-6,7-didehydro-4,5H-epoxy-3,6,14-trihydroxy-N-[2-(3-phenyl-1,2,4-oxadiazol-5-yl)propan-2-yl]morphinan-7-carboxamide 4-methylbenzenesulfonic acid tosylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1374774-70-5
C₃₄H₃₆N₄O₇

: 104-15-4
toluene-4-sulfonic acid

: 1345728-04-2
17-(cyclopropylmethyl)-6,7-didehydro-4,5H-epoxy-3,6,14-trihydroxy-N-[2-(3-phenyl-1,2,4-oxadiazol-5-yl)propan-2-yl]morphinan-7-carboxamide 4-methylbenzenesulfonic acid tosylate

Guidance literature:: C₃₄H₃₆N₄O₇; With potassium hydroxide; In water; isopropyl alcohol; at 80 ℃; for 5h;

toluene-4-sulfonic acid; In isopropyl alcohol;

Reference yield:

: 916072-89-4
Naldemedine

: 104-15-4
toluene-4-sulfonic acid

: 1345728-04-2
17-(cyclopropylmethyl)-6,7-didehydro-4,5H-epoxy-3,6,14-trihydroxy-N-[2-(3-phenyl-1,2,4-oxadiazol-5-yl)propan-2-yl]morphinan-7-carboxamide 4-methylbenzenesulfonic acid tosylate

Guidance literature:: In methanol; for 0.5h;

Reference yield:

: 613-92-3
N-hydroxybenzenecarboximidamide

: 1345728-04-2
17-(cyclopropylmethyl)-6,7-didehydro-4,5H-epoxy-3,6,14-trihydroxy-N-[2-(3-phenyl-1,2,4-oxadiazol-5-yl)propan-2-yl]morphinan-7-carboxamide 4-methylbenzenesulfonic acid tosylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1,1'-carbonyldiimidazole / acetonitrile / 1.5 h / 0 °C

1.2: 2 h / 0 °C

2.1: triethylamine; aluminum (III) chloride / toluene / 2.5 h / 50 °C

3.1: copper dichloride / water; ethyl acetate / 4 h / 25 °C

4.1: potassium hydroxide / water; isopropyl alcohol / 5 h / 80 °C

With aluminum (III) chloride; triethylamine; 1,1'-carbonyldiimidazole; potassium hydroxide; copper dichloride; In water; ethyl acetate; isopropyl alcohol; toluene; acetonitrile;