N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl) (2R)-6-((4-methoxybenzyl)oxy)-N,2-dimethylhexanamide

Base Information

Chemical Name:N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl) (2R)-6-((4-methoxybenzyl)oxy)-N,2-dimethylhexanamide
CAS No.:1385634-64-9
Molecular Formula:C₂₅H₃₅NO₄
Molecular Weight:413.557
Hs Code.:

Synonyms:N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl) (2R)-6-((4-methoxybenzyl)oxy)-N,2-dimethylhexanamide

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Chemical Property of N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl) (2R)-6-((4-methoxybenzyl)oxy)-N,2-dimethylhexanamide

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Technology Process of N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl) (2R)-6-((4-methoxybenzyl)oxy)-N,2-dimethylhexanamide

There total 4 articles about N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl) (2R)-6-((4-methoxybenzyl)oxy)-N,2-dimethylhexanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1385634-63-8
N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-6-((4-methoxybenzyl)oxy)-N-methylhexanamide

: 74-88-4
methyl iodide

: 1385634-64-9
N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl) (2R)-6-((4-methoxybenzyl)oxy)-N,2-dimethylhexanamide

Guidance literature:: N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-6-((4-methoxybenzyl)oxy)-N-methylhexanamide; With lithium chloride; lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 - 0 ℃; for 1.33h; Inert atmosphere;

methyl iodide; In tetrahydrofuran; hexane; at 0 ℃; for 0.333333h; enantioselective reaction; Inert atmosphere;
DOI:10.1021/jo301121f

Reference yield:

: ethyl 6-[(4-methoxybenzyl)oxy]hexanoate

: 1385634-64-9
N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl) (2R)-6-((4-methoxybenzyl)oxy)-N,2-dimethylhexanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / tetrahydrofuran; methanol; water / 60 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 20 °C / Inert atmosphere

2.2: 1 h / 0 °C / Inert atmosphere

3.1: lithium chloride; lithium diisopropyl amide / tetrahydrofuran; hexane / 1.33 h / -78 - 0 °C / Inert atmosphere

3.2: 0.33 h / 0 °C / Inert atmosphere

With oxalyl dichloride; N,N-dimethyl-formamide; lithium chloride; sodium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; methanol; hexane; dichloromethane; water;
DOI:10.1021/jo301121f

Reference yield:

: 343221-33-0
6-((4-methoxybenzyl)oxy)hexanoic acid

: 1385634-64-9
N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl) (2R)-6-((4-methoxybenzyl)oxy)-N,2-dimethylhexanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 20 °C / Inert atmosphere

1.2: 1 h / 0 °C / Inert atmosphere

2.1: lithium chloride; lithium diisopropyl amide / tetrahydrofuran; hexane / 1.33 h / -78 - 0 °C / Inert atmosphere

2.2: 0.33 h / 0 °C / Inert atmosphere

With oxalyl dichloride; N,N-dimethyl-formamide; lithium chloride; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/jo301121f