tert-butyl (4R)-4-((5S)-7-hydroxy-11,11-dimethyl-3-oxo-1,10,10-triphenyl-2,9-dioxa-4-aza-10-siladodecan-5-yl)-2,2-dimethyloxazolidine-3-carboxylate

Base Information

Chemical Name:tert-butyl (4R)-4-((5S)-7-hydroxy-11,11-dimethyl-3-oxo-1,10,10-triphenyl-2,9-dioxa-4-aza-10-siladodecan-5-yl)-2,2-dimethyloxazolidine-3-carboxylate
CAS No.:903907-78-8
Molecular Formula:C₃₈H₅₂N₂O₇Si
Molecular Weight:676.926
Hs Code.:

Synonyms:tert-butyl (4R)-4-((5S)-7-hydroxy-11,11-dimethyl-3-oxo-1,10,10-triphenyl-2,9-dioxa-4-aza-10-siladodecan-5-yl)-2,2-dimethyloxazolidine-3-carboxylate

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Chemical Property of tert-butyl (4R)-4-((5S)-7-hydroxy-11,11-dimethyl-3-oxo-1,10,10-triphenyl-2,9-dioxa-4-aza-10-siladodecan-5-yl)-2,2-dimethyloxazolidine-3-carboxylate

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Technology Process of tert-butyl (4R)-4-((5S)-7-hydroxy-11,11-dimethyl-3-oxo-1,10,10-triphenyl-2,9-dioxa-4-aza-10-siladodecan-5-yl)-2,2-dimethyloxazolidine-3-carboxylate

There total 11 articles about tert-butyl (4R)-4-((5S)-7-hydroxy-11,11-dimethyl-3-oxo-1,10,10-triphenyl-2,9-dioxa-4-aza-10-siladodecan-5-yl)-2,2-dimethyloxazolidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 903907-77-7
(4R)-((1S)-benzyloxycarbonylamino-3,4-dihydroxybutyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

: 58479-61-1
tert-butylchlorodiphenylsilane

: 903907-78-8
tert-butyl (4R)-4-((5S)-7-hydroxy-11,11-dimethyl-3-oxo-1,10,10-triphenyl-2,9-dioxa-4-aza-10-siladodecan-5-yl)-2,2-dimethyloxazolidine-3-carboxylate

Guidance literature:: With 1H-imidazole; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1021/jo060633h

Reference yield:

: 903907-76-6
(4R)-{(1S)-[benzyloxycarbonyl-(4-methoxy-benzyl)-amino]-3,4-dihydroxybutyl}-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

: 903907-78-8
tert-butyl (4R)-4-((5S)-7-hydroxy-11,11-dimethyl-3-oxo-1,10,10-triphenyl-2,9-dioxa-4-aza-10-siladodecan-5-yl)-2,2-dimethyloxazolidine-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / Pd/C / methanol / 24 h / 35 °C / 760 Torr

2: 14.1 g / aq. NaHCO₃ / ethyl acetate / 20 °C

3: 96 percent / imidazole / CH₂Cl₂ / 2 h / 20 °C

With 1H-imidazole; hydrogen; sodium hydrogencarbonate; palladium on activated charcoal; In methanol; dichloromethane; ethyl acetate;
DOI:10.1021/jo060633h

Reference yield:

: 903907-75-5
(R)-tert-butyl 4-((S)-1-((benzyloxycarbonyl)(4-methoxybenzyl)amino)but-3-enyl)-2,2-dimethyloxazolidine-3-carboxylate

: 903907-78-8
tert-butyl (4R)-4-((5S)-7-hydroxy-11,11-dimethyl-3-oxo-1,10,10-triphenyl-2,9-dioxa-4-aza-10-siladodecan-5-yl)-2,2-dimethyloxazolidine-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 89 percent / 4-methylmorpholine N-oxide; OsO₄ / acetone; H₂O; 2-methyl-propan-2-ol / 20 °C

2: H₂ / Pd/C / methanol / 24 h / 35 °C / 760 Torr

3: 14.1 g / aq. NaHCO₃ / ethyl acetate / 20 °C

4: 96 percent / imidazole / CH₂Cl₂ / 2 h / 20 °C

With 1H-imidazole; osmium(VIII) oxide; hydrogen; sodium hydrogencarbonate; 4-methylmorpholine N-oxide; palladium on activated charcoal; In methanol; dichloromethane; water; ethyl acetate; acetone; tert-butyl alcohol;
DOI:10.1021/jo060633h