(4R)-((1S)-benzyloxycarbonylamino-3,4-dihydroxybutyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

Base Information

Chemical Name:(4R)-((1S)-benzyloxycarbonylamino-3,4-dihydroxybutyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester
CAS No.:903907-77-7
Molecular Formula:C₂₂H₃₄N₂O₇
Molecular Weight:438.521
Hs Code.:

Synonyms:(4R)-((1S)-benzyloxycarbonylamino-3,4-dihydroxybutyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

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Chemical Property of (4R)-((1S)-benzyloxycarbonylamino-3,4-dihydroxybutyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

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Technology Process of (4R)-((1S)-benzyloxycarbonylamino-3,4-dihydroxybutyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

There total 11 articles about (4R)-((1S)-benzyloxycarbonylamino-3,4-dihydroxybutyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: tert-butyl (R)-4-((S)-1-(((benzyloxy)carbonyl)amino)but-3-en-1-yl)-2,2-dimethyloxazolidine-3-carboxylate

: 903907-77-7
(4R)-((1S)-benzyloxycarbonylamino-3,4-dihydroxybutyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

Guidance literature:: With osmium(VIII) oxide; 4-methylmorpholine N-oxide; In water; acetone; tert-butyl alcohol; for 8h;
DOI:10.1016/j.tetlet.2018.12.021

Reference yield:

: 903907-76-6
(4R)-{(1S)-[benzyloxycarbonyl-(4-methoxy-benzyl)-amino]-3,4-dihydroxybutyl}-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

: 903907-77-7
(4R)-((1S)-benzyloxycarbonylamino-3,4-dihydroxybutyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / Pd/C / methanol / 24 h / 35 °C / 760 Torr

2: 14.1 g / aq. NaHCO₃ / ethyl acetate / 20 °C

With hydrogen; sodium hydrogencarbonate; palladium on activated charcoal; In methanol; ethyl acetate;
DOI:10.1021/jo060633h

Reference yield:

: 903907-75-5
(R)-tert-butyl 4-((S)-1-((benzyloxycarbonyl)(4-methoxybenzyl)amino)but-3-enyl)-2,2-dimethyloxazolidine-3-carboxylate

: 903907-77-7
(4R)-((1S)-benzyloxycarbonylamino-3,4-dihydroxybutyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / 4-methylmorpholine N-oxide; OsO₄ / acetone; H₂O; 2-methyl-propan-2-ol / 20 °C

2: H₂ / Pd/C / methanol / 24 h / 35 °C / 760 Torr

3: 14.1 g / aq. NaHCO₃ / ethyl acetate / 20 °C

With osmium(VIII) oxide; hydrogen; sodium hydrogencarbonate; 4-methylmorpholine N-oxide; palladium on activated charcoal; In methanol; water; ethyl acetate; acetone; tert-butyl alcohol;
DOI:10.1021/jo060633h