6,7-dimethoxy-4-(2-hydroxyethyl)-3-(4-isopropyloxy-3-methoxyphenyl)-isoquinoline

Base Information

Chemical Name:6,7-dimethoxy-4-(2-hydroxyethyl)-3-(4-isopropyloxy-3-methoxyphenyl)-isoquinoline
CAS No.:1392399-33-5
Molecular Formula:C₂₃H₂₇NO₅
Molecular Weight:397.471
Hs Code.:

Synonyms:6,7-dimethoxy-4-(2-hydroxyethyl)-3-(4-isopropyloxy-3-methoxyphenyl)-isoquinoline

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Chemical Property of 6,7-dimethoxy-4-(2-hydroxyethyl)-3-(4-isopropyloxy-3-methoxyphenyl)-isoquinoline

Chemical Property:

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Technology Process of 6,7-dimethoxy-4-(2-hydroxyethyl)-3-(4-isopropyloxy-3-methoxyphenyl)-isoquinoline

There total 4 articles about 6,7-dimethoxy-4-(2-hydroxyethyl)-3-(4-isopropyloxy-3-methoxyphenyl)-isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1392399-30-2
4-(4-isopropyloxy-3-methoxyphenyl)-3-butyn-1-ol

: [1-(2-Bromo-4,5-dimethoxy-phenyl)-meth-(E)-ylidene]-tert-butyl-amine

: 1392399-33-5
6,7-dimethoxy-4-(2-hydroxyethyl)-3-(4-isopropyloxy-3-methoxyphenyl)-isoquinoline

: 1392399-34-6
6,7-dimethoxy-3-(2-hydroxyethyl)-4-(4-isopropyloxy-3-methoxyphenyl)isoquinoline

Guidance literature:: With dibromo[1,2-bis(diphenylphosphino)ethane]nickel(II); zinc; In acetonitrile; regioselective reaction; Reflux;
DOI:10.1016/j.bmc.2012.05.061

Reference yield:

: 7368-78-7
4-bromoguaiacol

: 1392399-33-5
6,7-dimethoxy-4-(2-hydroxyethyl)-3-(4-isopropyloxy-3-methoxyphenyl)-isoquinoline

: 1392399-34-6
6,7-dimethoxy-3-(2-hydroxyethyl)-4-(4-isopropyloxy-3-methoxyphenyl)isoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 20 - 90 °C

2: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; diisopropylamine / Reflux

3: dibromo[1,2-bis(diphenylphosphino)ethane]nickel(II); zinc / acetonitrile / Reflux

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; dibromo[1,2-bis(diphenylphosphino)ethane]nickel(II); potassium carbonate; diisopropylamine; zinc; In N,N-dimethyl-formamide; acetonitrile; 2: Sonogashira coupling;
DOI:10.1016/j.bmc.2012.05.061

Reference yield:

: 5392-10-9
2-bromo-4,5-dimethoxybenzaldehyde

: 1392399-33-5
6,7-dimethoxy-4-(2-hydroxyethyl)-3-(4-isopropyloxy-3-methoxyphenyl)-isoquinoline

: 1392399-34-6
6,7-dimethoxy-3-(2-hydroxyethyl)-4-(4-isopropyloxy-3-methoxyphenyl)isoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: 20 °C

2: dibromo[1,2-bis(diphenylphosphino)ethane]nickel(II); zinc / acetonitrile / Reflux

With dibromo[1,2-bis(diphenylphosphino)ethane]nickel(II); zinc; In acetonitrile;
DOI:10.1016/j.bmc.2012.05.061