6,7-dimethoxy-3-(4-isopropyloxy-3-methoxyphenyl)-4-(2-oxoethyl)isoquinoline

Base Information

Chemical Name:6,7-dimethoxy-3-(4-isopropyloxy-3-methoxyphenyl)-4-(2-oxoethyl)isoquinoline
CAS No.:1392399-36-8
Molecular Formula:C₂₃H₂₅NO₅
Molecular Weight:395.455
Hs Code.:

Synonyms:6,7-dimethoxy-3-(4-isopropyloxy-3-methoxyphenyl)-4-(2-oxoethyl)isoquinoline

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Chemical Property of 6,7-dimethoxy-3-(4-isopropyloxy-3-methoxyphenyl)-4-(2-oxoethyl)isoquinoline

Chemical Property:

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Technology Process of 6,7-dimethoxy-3-(4-isopropyloxy-3-methoxyphenyl)-4-(2-oxoethyl)isoquinoline

There total 4 articles about 6,7-dimethoxy-3-(4-isopropyloxy-3-methoxyphenyl)-4-(2-oxoethyl)isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1392399-33-5
6,7-dimethoxy-4-(2-hydroxyethyl)-3-(4-isopropyloxy-3-methoxyphenyl)-isoquinoline

: 1392399-36-8
6,7-dimethoxy-3-(4-isopropyloxy-3-methoxyphenyl)-4-(2-oxoethyl)isoquinoline

Guidance literature:: With oxalyl dichloride; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; In dichloromethane; at -78 ℃;
DOI:10.1016/j.bmc.2012.05.061

Reference yield:

: 5392-10-9
2-bromo-4,5-dimethoxybenzaldehyde

: 1392399-36-8
6,7-dimethoxy-3-(4-isopropyloxy-3-methoxyphenyl)-4-(2-oxoethyl)isoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: 20 °C

2: dibromo[1,2-bis(diphenylphosphino)ethane]nickel(II); zinc / acetonitrile / Reflux

3: oxalyl dichloride; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine / dichloromethane / -78 °C

With oxalyl dichloride; dibromo[1,2-bis(diphenylphosphino)ethane]nickel(II); dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; zinc; In dichloromethane; acetonitrile; 3: Swern oxidation;
DOI:10.1016/j.bmc.2012.05.061

Reference yield:

: 138505-27-8
4-bromo-1-isopropoxy-2-methoxy-benzene

: 1392399-36-8
6,7-dimethoxy-3-(4-isopropyloxy-3-methoxyphenyl)-4-(2-oxoethyl)isoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; diisopropylamine / Reflux

2: dibromo[1,2-bis(diphenylphosphino)ethane]nickel(II); zinc / acetonitrile / Reflux

3: oxalyl dichloride; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine / dichloromethane / -78 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; oxalyl dichloride; dibromo[1,2-bis(diphenylphosphino)ethane]nickel(II); dimethyl sulfoxide; diisopropylamine; N-ethyl-N,N-diisopropylamine; zinc; In dichloromethane; acetonitrile; 1: Sonogashira coupling / 3: Swern oxidation;
DOI:10.1016/j.bmc.2012.05.061