Technology Process of 3-[1-benzenesulfonyl-2-hydroxy-2-(1-methyl-cyclohexa-2,5-dienyl)-ethyl]-2,2,4-trimethyl-cyclohex-3-enecarbaldehyde
There total 10 articles about 3-[1-benzenesulfonyl-2-hydroxy-2-(1-methyl-cyclohexa-2,5-dienyl)-ethyl]-2,2,4-trimethyl-cyclohex-3-enecarbaldehyde which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
tetrapropylammonium perruthennate; 4 A molecular sieve; 4-methylmorpholine N-oxide;
In
dichloromethane;
at 20 ℃;
for 0.25h;
DOI:10.1039/b005727o
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: NaBH4 / methanol / 0 °C
2.1: DMAP; Et3N / CH2Cl2 / 0 - 20 °C
3.1: DIBAL-H / diethyl ether / 0 °C
4.1: 95 percent / pyridine; Bu3P / 9 h / 20 °C
5.1: oxone / tetrahydrofuran; methanol; H2O / 4 h / 20 °C
6.1: DMAP; Et3N / CH2Cl2 / 20 °C
7.1: LDA / tetrahydrofuran; hexane / 0.5 h / 0 °C
7.2: tetrahydrofuran; hexane / 1 h / -78 °C
8.1: 92 percent / HF*pyridine / tetrahydrofuran / 5 h / 20 °C
9.1: 100 percent / 4-methylmorpholine N-oxide; 4 Angstroem molecular sieves; TPAP / CH2Cl2 / 0.25 h / 20 °C
With
pyridine; dmap; Oxone; sodium tetrahydroborate; tetrapropylammonium perruthennate; tributylphosphine; 4 A molecular sieve; diisobutylaluminium hydride; pyridine hydrogenfluoride; 4-methylmorpholine N-oxide; triethylamine; lithium diisopropyl amide;
In
tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; water;
1.1: Reduction / 2.1: Etherification / 3.1: Reduction / 4.1: Substitution / 5.1: Oxidation / 6.1: Etherification / 7.1: Metallation / 7.2: Substitution / 8.1: Substitution / 9.1: Oxidation;
DOI:10.1039/b005727o
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: 82 percent / BF3*Et2O / CH2Cl2 / -78 °C
2.1: NaBH4 / methanol / 0 °C
3.1: DMAP; Et3N / CH2Cl2 / 0 - 20 °C
4.1: DIBAL-H / diethyl ether / 0 °C
5.1: 95 percent / pyridine; Bu3P / 9 h / 20 °C
6.1: oxone / tetrahydrofuran; methanol; H2O / 4 h / 20 °C
7.1: DMAP; Et3N / CH2Cl2 / 20 °C
8.1: LDA / tetrahydrofuran; hexane / 0.5 h / 0 °C
8.2: tetrahydrofuran; hexane / 1 h / -78 °C
9.1: 92 percent / HF*pyridine / tetrahydrofuran / 5 h / 20 °C
10.1: 100 percent / 4-methylmorpholine N-oxide; 4 Angstroem molecular sieves; TPAP / CH2Cl2 / 0.25 h / 20 °C
With
pyridine; dmap; Oxone; sodium tetrahydroborate; tetrapropylammonium perruthennate; tributylphosphine; 4 A molecular sieve; boron trifluoride diethyl etherate; diisobutylaluminium hydride; pyridine hydrogenfluoride; 4-methylmorpholine N-oxide; triethylamine; lithium diisopropyl amide;
In
tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; water;
1.1: Cycloaddition / 2.1: Reduction / 3.1: Etherification / 4.1: Reduction / 5.1: Substitution / 6.1: Oxidation / 7.1: Etherification / 8.1: Metallation / 8.2: Substitution / 9.1: Substitution / 10.1: Oxidation;
DOI:10.1039/b005727o
![5-Hydroxymethyl-1-[2-(1-methylcyclohexa-2,5-dien-1-yl)-2-hydroxy-1-phenylsulfonylethyl]-2,6,6-trimethylcyclohex-1-ene](/Databaselist/images/loading.webp)
