144067-40-3

Upstream product

• 144066-82-0 Acetic acid 2-isopropenyl-3-methyl-but-2-enyl ester 
• 107-02-8 acrolein 
• 52385-60-1 (3-methyl-2-methylethenyl)-2-buten-1-ol 
• 99978-27-5 2-(α-hydroxy-isopropyl)-3-methyl-crotonic acid ethyl ester 
• 100144-50-1 2-isopropenyl-3-methyl-crotonic acid methyl ester 
• 4412-05-9 2-isopropenyl-3-methyl-crotonic acid 
• 35044-52-1 ethyl 2-acetyl-3-methylbut-2-enoate 

Downstream Products

• 216978-73-3 1-Acetoxymethyl-5-(1-hydroxyprop-2-enyl)-2,6,6-trimethylcyclohex-1-ene 
• 216978-13-1 1-Acetoxymethyl-5-(1,3-dioxolan-2-yl)-2,6,6-trimethylcyclohex-1-ene 
• 216978-34-6 1-Acetoxymethyl-5-hydroxymethyl-2,6,6-trimethylcyclohex-1-ene 
• 216978-17-5 1-Acetoxymethyl-5-(1-hydroxyprop-2-ynyl)-2,6,6-trimethylcyclohex-1-ene 
• 925212-41-5 [5-((E)-6-[tert-butyldimethylsilyloxy]-1-hydroxy-2-hexenyl)-2,6,6-trimethyl-1-cyclohexenyl]methyl acetate 
• 144067-42-5 1-Formyl-5-(1-hydroxyprop-2-enyl)-2,6,6-trimethylcyclohex-1-ene 
• 144067-46-9 1-((E)-6-Bromo-1-oxohex-2-enyl)-2,6,6-trimethyl-5-(1-oxoprop-2-enyl)cyclohex-1-ene 
• 144067-39-0 1-((E)-6-Iodo-1-oxohex-2-enyl)-2,6,6-trimethyl-5-(1-oxoprop-2-enyl)cyclohex-1-ene 
• 144067-44-7 1-((E)-6-Bromo-1-hydroxyhex-2-enyl)-2,6,6-trimethyl-5-(1-hydroxyprop-2-enyl)cyclohex-1-ene 
• 174788-18-2 5-(tert-Butyl-dimethyl-silanyloxymethyl)-2,6,6-trimethyl-cyclohex-1-enecarbaldehyde 
• 189443-99-0 1-Formyl-5-(1,3-dioxolan-2-yl)-2,6,6-trimethylcyclohex-1-ene 
• 189444-04-0 1-(6-Bromo-1-oxohex-2-enyl)-5-formyl-2,6,6-trimethylcyclohex-1-ene 
• 189444-01-7 5-Formyl-1-(6-chloro-1-oxohex-2-ynyl)-2,6,6-trimethylcyclohex-1-ene 
• 189444-02-8 1-(6-Chloro-1-oxohex-2-ynyl)-5-(1-oxoprop-2-enyl)-2,6,6-trimethylcyclohex-1-ene 

Relevant academic research and scientific papers

The unexpected formation of bicyclo[2.2.1]heptane derivatives by Lewis acid-catalyzed transannular double cyclization

Attempted synthesis of the cyclooctanoid skeleton of taxane molecules, by an intramolecular Lewis acid catalyzed Hosomi-Sakurai cyclization of the allylsilane with the aldehyde moiety in 17, unexpectedly led to the formation of bicyclo[2.2.1]-heptane deri

A tandem radical macrocyclisation-transannular cyclisation approach towards the taxanes

Separate treatment of the iodotrienedione 19 and the iododienynedione 38 with Bu3SnH-AIBN produces the corresponding taxane ring systems 25 (25-30%) and 56 (50-60%) respectively by way of tandem radical macrocyclisation-radical transannular cyc

A tandem radical macrocyclisation - Radical transannulation strategy to the taxane ring system

Treatment of the iodo-trienone (8 b) with tri-n-butyltin hydride in the presence of AIBN is shown to produce the taxane ring system (11) by way of a tandem radical macrocyclisation - radical transannulation sequence, i.e. (8 b) → (9) → (11) (cf. Scheme 1)