2-(3-chloro-4-methanesulfonyl-phenyl)-3-(3-oxo-cyclopentyl)-propionic acid

Base Information

• Chemical Name: 2-(3-chloro-4-methanesulfonyl-phenyl)-3-(3-oxo-cyclopentyl)-propionic acid
• CAS No.: 625114-33-2
• Molecular Formula: C₁₅H₁₇ClO₅S
• Molecular Weight: 344.816
• Mol file: 625114-33-2.mol

Synonyms:2-(3-chloro-4-methanesulfonyl-phenyl)-3-(3-oxo-cyclopentyl)-propionic acid

Chemical Property of 2-(3-chloro-4-methanesulfonyl-phenyl)-3-(3-oxo-cyclopentyl)-propionic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3-chloro-4-methanesulfonyl-phenyl)-3-(3-oxo-cyclopentyl)-propionic acid

There total 4 articles about 2-(3-chloro-4-methanesulfonyl-phenyl)-3-(3-oxo-cyclopentyl)-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

2-(3-chloro-4-methanesulfonyl-phenyl)-3-(3-oxo-cyclopentyl)-propionic acid methyl ester → 2-(3-chloro-4-methanesulfonyl-phenyl)-3-(3-oxo-cyclopentyl)-propionic acid (625114-33-2)

Guidance literature:

With sodium hydroxide; In methanol; water; at 25 ℃; for 16h;

Reference yield:

cyclopentanone (120-92-3) → 2-(3-chloro-4-methanesulfonyl-phenyl)-3-(3-oxo-cyclopentyl)-propionic acid (625114-33-2)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrakis(tetrabutylammonium)decatungstate(VI); 4,4'-di-tert-butyl-2,2'-bipyridine nickel(II) bromide; potassium phosphate / acetone / 18 h / 30 °C / Inert atmosphere; Sealed tube; Irradiation

2: lithium hydroxide; water / 24 h / 0 - 20 °C

With potassium phosphate; tetrakis(tetrabutylammonium)decatungstate(VI); 4,4'-di-tert-butyl-2,2'-bipyridine nickel(II) bromide; water; lithium hydroxide; In acetone;

DOI:10.1002/anie.202014632

Reference yield:

benzyl 2-(3-chloro-4-(methylsulfonyl)phenyl)-3-(3-oxocyclopentyl)propanoate → 2-(3-chloro-4-methanesulfonyl-phenyl)-3-(3-oxo-cyclopentyl)-propionic acid (625114-33-2)

Guidance literature:

With water; lithium hydroxide; at 0 - 20 ℃; for 24h;

DOI:10.1002/anie.202014632

upstream raw materials:

cyclopentanone

4-bromo-2-chloro-1-(methylsulfonyl)benzene

Downstream raw materials:

N-(5-bromo-pyrazin-2-yl)-2-(3-chloro-4-methanesulfonyl-phenyl)-3-(3-oxo-cyclopentyl)-propionamide

2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-(3-oxo-cyclopentyl)-N-pyrazin-2-yl-propionamide