2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-(3-oxo-cyclopentyl)-N-pyrazin-2-yl-propionamide

Base Information

Chemical Name:2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-(3-oxo-cyclopentyl)-N-pyrazin-2-yl-propionamide
CAS No.:625114-26-3
Molecular Formula:C₁₉H₂₀ClN₃O₄S
Molecular Weight:421.904
Hs Code.:

Synonyms:2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-(3-oxo-cyclopentyl)-N-pyrazin-2-yl-propionamide

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Chemical Property of 2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-(3-oxo-cyclopentyl)-N-pyrazin-2-yl-propionamide

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Technology Process of 2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-(3-oxo-cyclopentyl)-N-pyrazin-2-yl-propionamide

There total 5 articles about 2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-(3-oxo-cyclopentyl)-N-pyrazin-2-yl-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 5049-61-6
2-Aminopyrazine

: 625114-33-2
2-(3-chloro-4-methanesulfonyl-phenyl)-3-(3-oxo-cyclopentyl)-propionic acid

: 625114-26-3
2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-(3-oxo-cyclopentyl)-N-pyrazin-2-yl-propionamide

Guidance literature:: 2-(3-chloro-4-methanesulfonyl-phenyl)-3-(3-oxo-cyclopentyl)-propionic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 0 - 25 ℃; for 2.25h;

2-Aminopyrazine; With pyridine; In tetrahydrofuran; at 0 - 25 ℃; for 2.25h;

Reference yield:

: 5049-61-6
2-Aminopyrazine

: C₁₅H₁₆Cl₂O₄S

: 625114-26-3
2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-(3-oxo-cyclopentyl)-N-pyrazin-2-yl-propionamide

Guidance literature:: With pyridine; In tetrahydrofuran; at 20 ℃; for 24h; Inert atmosphere;
DOI:10.1002/anie.202014632

Reference yield:

: 648905-09-3
4-bromo-2-chloro-1-(methylsulfonyl)benzene

: 625114-26-3
2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-(3-oxo-cyclopentyl)-N-pyrazin-2-yl-propionamide

Guidance literature:: Multi-step reaction with 4 steps

1: tetrakis(tetrabutylammonium)decatungstate(VI); 4,4'-di-tert-butyl-2,2'-bipyridine nickel(II) bromide; potassium phosphate / acetone / 18 h / 30 °C / Inert atmosphere; Sealed tube; Irradiation

2: lithium hydroxide; water / 24 h / 0 - 20 °C

3: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1.17 h / 0 - 20 °C / Inert atmosphere

4: pyridine / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere

With pyridine; potassium phosphate; oxalyl dichloride; tetrakis(tetrabutylammonium)decatungstate(VI); 4,4'-di-tert-butyl-2,2'-bipyridine nickel(II) bromide; water; N,N-dimethyl-formamide; lithium hydroxide; In tetrahydrofuran; dichloromethane; acetone;
DOI:10.1002/anie.202014632