N-t-butoxycarbonyl-1-hexyl-2-[4-methoxy-3-(2-phenylethoxy)-phenyl]ethylamine

Base Information

Chemical Name:N-t-butoxycarbonyl-1-hexyl-2-[4-methoxy-3-(2-phenylethoxy)-phenyl]ethylamine
CAS No.:177587-26-7
Molecular Formula:C₂₈H₄₁NO₄
Molecular Weight:455.638
Hs Code.:

Synonyms:N-t-butoxycarbonyl-1-hexyl-2-[4-methoxy-3-(2-phenylethoxy)-phenyl]ethylamine

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Chemical Property of N-t-butoxycarbonyl-1-hexyl-2-[4-methoxy-3-(2-phenylethoxy)-phenyl]ethylamine

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Technology Process of N-t-butoxycarbonyl-1-hexyl-2-[4-methoxy-3-(2-phenylethoxy)-phenyl]ethylamine

There total 6 articles about N-t-butoxycarbonyl-1-hexyl-2-[4-methoxy-3-(2-phenylethoxy)-phenyl]ethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 111-25-1
1-bromo-hexane

: 177587-26-7
N-t-butoxycarbonyl-1-hexyl-2-[4-methoxy-3-(2-phenylethoxy)-phenyl]ethylamine

Guidance literature:: Multi-step reaction with 5 steps

1.1: NaH / 1,2-dimethoxy-ethane / 1 h / 20 °C

1.2: 1,2-dimethoxy-ethane / 3 h / Heating

2.1: NaH / 1,2-dimethoxy-ethane / 0.5 h / 20 °C

2.2: 1,2-dimethoxy-ethane / 2 h / Heating

3.1: H₂ / 5 percent Pd/C / ethanol

4.1: aq. KOH / ethanol

5.1: diphenyl phosphorazidate, Et₃N / benzene / 2 h / Heating

5.2: 20 h / Heating

With potassium hydroxide; diphenyl phosphoryl azide; hydrogen; sodium hydride; triethylamine; palladium on activated charcoal; In 1,2-dimethoxyethane; ethanol; benzene; 1.1: Metallation / 1.2: Alkylation / 2.1: Metallation / 2.2: Horner-Emmons condensation / 3.1: Hydrogenation / 4.1: Hydrolysis / 5.1: modified Curtius reaction / 5.2: Alkylation;
DOI:10.1021/jm990135j

Reference yield:

: 40226-04-8
ethyl 2-(diethoxyphosphoryl)octanoate

: 177587-26-7
N-t-butoxycarbonyl-1-hexyl-2-[4-methoxy-3-(2-phenylethoxy)-phenyl]ethylamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: NaH / 1,2-dimethoxy-ethane / 0.5 h / 20 °C

1.2: 1,2-dimethoxy-ethane / 2 h / Heating

2.1: H₂ / 5 percent Pd/C / ethanol

3.1: aq. KOH / ethanol

4.1: diphenyl phosphorazidate, Et₃N / benzene / 2 h / Heating

4.2: 20 h / Heating

With potassium hydroxide; diphenyl phosphoryl azide; hydrogen; sodium hydride; triethylamine; palladium on activated charcoal; In 1,2-dimethoxyethane; ethanol; benzene; 1.1: Metallation / 1.2: Horner-Emmons condensation / 2.1: Hydrogenation / 3.1: Hydrolysis / 4.1: modified Curtius reaction / 4.2: Alkylation;
DOI:10.1021/jm990135j

Reference yield:

: 2-[1-(4-Methoxy-3-phenethyloxy-phenyl)-meth-(E)-ylidene]-octanoic acid ethyl ester

: 177587-26-7
N-t-butoxycarbonyl-1-hexyl-2-[4-methoxy-3-(2-phenylethoxy)-phenyl]ethylamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: H₂ / 5 percent Pd/C / ethanol

2.1: aq. KOH / ethanol

3.1: diphenyl phosphorazidate, Et₃N / benzene / 2 h / Heating

3.2: 20 h / Heating

With potassium hydroxide; diphenyl phosphoryl azide; hydrogen; triethylamine; palladium on activated charcoal; In ethanol; benzene; 1.1: Hydrogenation / 2.1: Hydrolysis / 3.1: modified Curtius reaction / 3.2: Alkylation;
DOI:10.1021/jm990135j